MedBlast(0.8) Results

• Direct References
• Indirect References
• Options
• BLASTN
• BLASTX

Direct References:

References Summary:

1. Fani R, Tamburini E, Mori E, Lazcano A, Lio P, Barberio C, Casalone E, Cavalieri D, Perito B, Polsinelli M
   Paralogous histidine biosynthetic genes: evolutionary analysis of the Saccharomyces cerevisiae HIS6 and HIS7 genes.
   Gene 1997 Sep 15;197(1-2):9-17
   PMID: 9332345
2. Kolodziej P, Young RA
   RNA polymerase II subunit RPB3 is an essential component of the mRNA transcription apparatus.
   Mol Cell Biol 1989 Dec;9(12):5387-94
   PMID: 2685562

Indirect References:

References Summary:

1. Altmann M, Wittmer B, Methot N, Sonenberg N, Trachsel H
   The Saccharomyces cerevisiae translation initiation factor Tif3 and its mammalian homologue, eIF-4B, have RNA annealing activity.
   EMBO J 1995 Aug 1;14(15):3820-7
   PMID: 7543843
2. Motorin Y, Grosjean H
   Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme.
   RNA 1999 Aug;5(8):1105-18
   PMID: 10445884
3. Kaslow DC, Kumar S
   Expression and immunogenicity of the C-terminus of a major blood-stage surface protein of Plasmodium vivax, Pv200(19), secreted from Saccharomyces cerevisiae.
   Immunol Lett 1996 Jul;51(3):187-9
   PMID: 8832290
4. Borsig L, Berger EG, Malissard M
   Expression and purification of His-tagged beta-1,4-galactosyltransferase in yeast and in COS cells.
   Biochem Biophys Res Commun 1997 Nov 26;240(3):586-9
   PMID: 9398608
5. Lamontagne B, Elela SA
   Purification and characterization of Saccharomyces cerevisiae Rnt1p nuclease.
   Methods Enzymol 2001;342:159-67
   PMID: 11586890
6. Enomoto S, Chen G, Berman J
   Vectors for expressing T7 epitope- and His6 affinity-tagged fusion proteins in S. cerevisiae.
   Biotechniques 1998 May;24(5):782-6, 788
   PMID: 9591127
7. Fang Y, Fliss AE, Rao J, Caplan AJ
   SBA1 encodes a yeast hsp90 cochaperone that is homologous to vertebrate p23 proteins.
   Mol Cell Biol 1998 Jul;18(7):3727-34
   PMID: 9632755
8. Denis V, Boucherie H, Monribot C, Daignan-Fornier B
   Role of the myb-like protein bas1p in Saccharomyces cerevisiae: a proteome analysis.
   Mol Microbiol 1998 Nov;30(3):557-66
   PMID: 9822821
9. Cannon JF, Gibbs JB, Tatchell K
   Suppressors of the ras2 mutation of Saccharomyces cerevisiae.
   Genetics 1986 Jun;113(2):247-64
   PMID: 3013722
10. Fox T, English AM, Gibbs BF
    Derivatization of yeast cytochrome c peroxidase with pentaammineruthenium(III).
    Bioconjug Chem 1994 Jan-Feb;5(1):14-20
    PMID: 8199229
11. Beeler T, Bacikova D, Gable K, Hopkins L, Johnson C, Slife H, Dunn T
    The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant.
    J Biol Chem 1998 Nov 13;273(46):30688-94
    PMID: 9804843
12. Tang BL, Peter F, Krijnse-Locker J, Low SH, Griffiths G, Hong W
    The mammalian homolog of yeast Sec13p is enriched in the intermediate compartment and is essential for protein transport from the endoplasmic reticulum to the Golgi apparatus.
    Mol Cell Biol 1997 Jan;17(1):256-66
    PMID: 8972206
13. Ghosh S, Lowenstein JM
    A multifunctional vector system for heterologous expression of proteins in Escherichia coli. Expression of native and hexahistidyl fusion proteins, rapid purification of the fusion proteins, and removal of fusion peptide by Kex2 protease.
    Gene 1996 Oct 17;176(1-2):249-55
    PMID: 8918261
14. Fox T, Ferreira-Rajabi L, Hill BC, English AM
    Quenching of intrinsic fluorescence of yeast cytochrome c peroxidase by covalently- and noncovalently-bound quenchers.
    Biochemistry 1993 Jul 13;32(27):6938-43
    PMID: 8392866
15. Stolz J, Stadler R, Opekarova M, Sauer N
    Functional reconstitution of the solubilized Arabidopsis thaliana STP1 monosaccharide-H+ symporter in lipid vesicles and purification of the histidine tagged protein from transgenic Saccharomyces cerevisiae.
    Plant J 1994 Aug;6(2):225-33
    PMID: 7920712
16. Andersen B, Stevens RC
    The human D1A dopamine receptor: heterologous expression in Saccharomyces cerevisiae and purification of the functional receptor.
    Protein Expr Purif 1998 Jun;13(1):111-9
    PMID: 9631523
17. Lee MG, Lee JY, Song HK, Suh SW
    Crystallization and preliminary X-ray analysis of Saccharomyces cerevisiae Ypd1p, a key intermediate in phosphorelay signal transduction.
    Acta Crystallogr D Biol Crystallogr 1999 Jun;55 ( Pt 6):1219-21
    PMID: 10329790
18. Kozhina T, Kozhin S, Stepanova V, Yarovoy B, Donich V, Fedorova I, Korolev V
    UVS112--A gene involved in excision repair of yeast.
    Yeast 1995 Sep 30;11(12):1129-38
    PMID: 8619311
19. Flick JS, Thorner J
    Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiae.
    Mol Cell Biol 1993 Sep;13(9):5861-76
    PMID: 8395015
20. Koppel DA, Kinnally KW, Masters P, Forte M, Blachly-Dyson E, Mannella CA
    Bacterial expression and characterization of the mitochondrial outer membrane channel. Effects of n-terminal modifications.
    J Biol Chem 1998 May 29;273(22):13794-800
    PMID: 9593723
21. Gozar MM, Price VL, Kaslow DC
    Saccharomyces cerevisiae-secreted fusion proteins Pfs25 and Pfs28 elicit potent Plasmodium falciparum transmission-blocking antibodies in mice.
    Infect Immun 1998 Jan;66(1):59-64
    PMID: 9423839
22. Hagting A, Knol J, Hasemeier B, Streutker MR, Fang G, Poolman B, Konings WN
    Amplified expression, purification and functional reconstitution of the dipeptide and tripeptide transport protein of Lactococcus lactis.
    Eur J Biochem 1997 Jul 15;247(2):581-7
    PMID: 9266700
23. David NE, Gee M, Andersen B, Naider F, Thorner J, Stevens RC
    Expression and purification of the Saccharomyces cerevisiae alpha-factor receptor (Ste2p), a 7-transmembrane-segment G protein-coupled receptor.
    J Biol Chem 1997 Jun 13;272(24):15553-61
    PMID: 9182592
24. Hollingsworth NM, Byers B
    HOP1: a yeast meiotic pairing gene.
    Genetics 1989 Mar;121(3):445-62
    PMID: 2653960
25. Armstrong LC, Saenz AJ, Bornstein P
    Metaxin 1 interacts with metaxin 2, a novel related protein associated with the mammalian mitochondrial outer membrane.
    J Cell Biochem 1999 Jul 1;74(1):11-22
    PMID: 10381257
26. Becker HF, Motorin Y, Planta RJ, Grosjean H
    The yeast gene YNL292w encodes a pseudouridine synthase (Pus4) catalyzing the formation of psi55 in both mitochondrial and cytoplasmic tRNAs.
    Nucleic Acids Res 1997 Nov 15;25(22):4493-9
    PMID: 9358157
27. Hanada K, Hara T, Nishijima M, Kuge O, Dickson RC, Nagiec MM
    A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis.
    J Biol Chem 1997 Dec 19;272(51):32108-14
    PMID: 9405408
28. Ghanevati M, Jaworski JG
    Engineering and mechanistic studies of the Arabidopsis FAE1 beta-ketoacyl-CoA synthase, FAE1 KCS.
    Eur J Biochem 2002 Jul;269(14):3531-9
    PMID: 12135493
29. Kotova I, Chabes AL, Segerman B, Flodell S, Thelander L, Bjorklund S
    A mouse in vitro transcription system reconstituted from highly purified RNA polymerase II, TFIIH and recombinant TBP, TFIIB, TFIIE and TFIIF.
    Eur J Biochem 2001 Aug;268(16):4527-36
    PMID: 11502214
30. Lecointe F, Simos G, Sauer A, Hurt EC, Motorin Y, Grosjean H
    Characterization of yeast protein Deg1 as pseudouridine synthase (Pus3) catalyzing the formation of psi 38 and psi 39 in tRNA anticodon loop.
    J Biol Chem 1998 Jan 16;273(3):1316-23
    PMID: 9430663
31. Sauer N, Stolz J
    SUC1 and SUC2: two sucrose transporters from Arabidopsis thaliana; expression and characterization in baker's yeast and identification of the histidine-tagged protein.
    Plant J 1994 Jul;6(1):67-77
    PMID: 7920705
32. Sata M, Donaldson JG, Moss J, Vaughan M
    Brefeldin A-inhibited guanine nucleotide-exchange activity of Sec7 domain from yeast Sec7 with yeast and mammalian ADP ribosylation factors.
    Proc Natl Acad Sci U S A 1998 Apr 14;95(8):4204-8
    PMID: 9539714
33. Svetlov V, Nolan K, Burgess RR
    Rpb3, stoichiometry and sequence determinants of the assembly into yeast RNA polymerase II in vivo.
    J Biol Chem 1998 May 1;273(18):10827-30
    PMID: 9556554
34. Coe JG, Lim AC, Xu J, Hong W
    A role for Tlg1p in the transport of proteins within the Golgi apparatus of Saccharomyces cerevisiae.
    Mol Biol Cell 1999 Jul;10(7):2407-23
    PMID: 10397773
35. Harris JD, Seid CA, Fontenot GK, Liu HF
    Expression and purification of recombinant human zona pellucida proteins.
    Protein Expr Purif 1999 Jul;16(2):298-307
    PMID: 10419825
36. Zhao R, Reithmeier RA
    Expression and characterization of the anion transporter homologue YNL275w in Saccharomyces cerevisiae.
    Am J Physiol Cell Physiol 2001 Jul;281(1):C33-45
    PMID: 11401825
37. Constantinesco F, Motorin Y, Grosjean H
    Characterisation and enzymatic properties of tRNA(guanine 26, N (2), N (2))-dimethyltransferase (Trm1p) from Pyrococcus furiosus.
    J Mol Biol 1999 Aug 13;291(2):375-92
    PMID: 10438627
38. Fujimori K, Tada S, Kanai S, Ohta D
    Molecular cloning and characterization of the gene encoding N'-[(5'-phosphoribosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide (BBM II) isomerase from Arabidopsis thaliana.
    Mol Gen Genet 1998 Aug;259(2):216-23
    PMID: 9747713
39. Magdolen V, Rettenberger P, Koppitz M, Goretzki L, Kessler H, Weidle UH, Konig B, Graeff H, Schmitt M, Wilhelm O
    Systematic mutational analysis of the receptor-binding region of the human urokinase-type plasminogen activator.
    Eur J Biochem 1996 May 1;237(3):743-51
    PMID: 8647121

Options:

• Limit of E-value: 1e-20
• Limit of Length: 100000
• Limit of references returned each search: 40
• Limit of retry times: 3
• Direct references: Yes
• Indirect references: Yes
• Allow symbol with hyphen: Yes
• Use stop word list: Yes
• Thesaurus:
  • Saccharomyces cerevisiae (Version: 20021123.0)

 
BLASTN 2.2.5 [Nov-16-2002]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.
RID: 1048252474-010485-20285
Query= ORFN:YIL020C HIS6 SGDID:S0001282, Chr IX from 314033-314818,
reverse complement
         (786 letters)

Database: All GenBank+EMBL+DDBJ+PDB sequences (but no EST, STS, GSS,
or phase 0, 1 or 2 HTGS sequences) 
           1,707,549 sequences; 7,931,913,529 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|2584816|emb|X87341.1|SCHIS6GEN S.cerevisiae gene for phosphor...  1558   0.0  
gi|599967|emb|Z46881.1|SC3299 S.cerevisiae chromosome IX cosmid ...  1558   0.0  
gi|172212|gb|M27496.1|YSCPOL2RPB Yeast (S.cerevisiae) RNA polyme...  1558   0.0  
gi|218538|dbj|D10933.1|YSPMFACR S.pombe map3 gene for M-factor r...    58   2e-05
gi|1182047|emb|Z69369.1|SPAC3F10 S.pombe chromosome I cosmid c3F10     58   2e-05
gi|28828213|gb|AC115612.2| Dictyostelium discoideum chromosome 2...    42   1.3  
gi|21541922|gb|AC091563.9| Homo sapiens chromosome 8, clone RP11...    42   1.3  
gi|25004486|emb|AL591478.19| Mouse DNA sequence from clone RP23-...    42   1.3  
gi|28971755|dbj|AP005624.3| Homo sapiens genomic DNA, chromosome...    42   1.3  
gi|13603463|dbj|AP003504.1| Oryza sativa (japonica cultivar-grou...    42   1.3  
gi|25188171|dbj|AP005717.3| Homo sapiens genomic DNA, chromosome...    42   1.3  
gi|18572222|ref|XM_098872.1| Homo sapiens LOC158088 (LOC158088),...    40   5.0  
gi|15638734|gb|AC092593.2| Homo sapiens BAC clone RP11-68D16 fro...    40   5.0  
gi|28270119|emb|AL935253.1| Lactobacillus plantarum strain WCFS1...    40   5.0  
gi|1495659|emb|X94434.1|LPATOVGNS L.plantarum pln[A,B,C,D,E,F,G,...    40   5.0  
gi|8894643|emb|AL109942.13|HSJ473J16 Human DNA sequence from clo...    40   5.0  
gi|15795446|emb|AL450105.17| Human DNA sequence from clone RP11-...    40   5.0  
gi|11414487|emb|AL157877.11| Human DNA sequence from clone RP11-...    40   5.0  
gi|3845417|gb|AC004837.1|AC004837 Homo sapiens PAC clone RP4-570...    40   5.0  
gi|2911720|gb|AC004226.1|AC004226 Homo sapiens chromosome 5, BAC...    40   5.0  
gi|21212599|emb|AL732402.5| Mouse DNA sequence from clone RP23-4...    40   5.0  
gi|10436870|dbj|AK024561.1| Homo sapiens cDNA: FLJ20908 fis, clo...    40   5.0  

ALIGNMENTS
>gi|2584816|emb|X87341.1|SCHIS6GEN S.cerevisiae gene for
            phosphoribosyl-5-amino-1-phosphoribosyl-4-
            imidazolecarboxamide isomerase
          Length = 1521

 Score = 1558 bits (786), Expect = 0.0
 Identities = 786/786 (100%)
 Strand = Plus / Plus

                                                                        
Query: 1    atgacgaagtttattggttgtatagacctgcataatggagaggttaaacagattgtaggt 60
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 347  atgacgaagtttattggttgtatagacctgcataatggagaggttaaacagattgtaggt 406

                                                                        
Query: 61   ggaacgttaacgagcaaaaaggaggacgttccaaaaactaactttgtatcacaacatcct 120
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 407  ggaacgttaacgagcaaaaaggaggacgttccaaaaactaactttgtatcacaacatcct 466

                                                                        
Query: 121  tcttcatattacgctaaactttacaaagacagagatgtccaaggatgtcatgttattaag 180
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 467  tcttcatattacgctaaactttacaaagacagagatgtccaaggatgtcatgttattaag 526

                                                                        
Query: 181  ttgggacctaacaatgacgacgctgcacgcgaggcactccaggagtcaccacaatttcta 240
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 527  ttgggacctaacaatgacgacgctgcacgcgaggcactccaggagtcaccacaatttcta 586

                                                                        
Query: 241  caagtgggcggaggaattaatgatacgaactgtttggaatggttaaaatgggccagtaaa 300
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 587  caagtgggcggaggaattaatgatacgaactgtttggaatggttaaaatgggccagtaaa 646

                                                                        
Query: 301  gtaattgttacgagttggctatttacaaaagagggtcattttcaattaaaaaggttagaa 360
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 647  gtaattgttacgagttggctatttacaaaagagggtcattttcaattaaaaaggttagaa 706

                                                                        
Query: 361  agactgacagaactatgtgggaaagaccgcattgttgtagacttaagctgtagaaaaacc 420
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 707  agactgacagaactatgtgggaaagaccgcattgttgtagacttaagctgtagaaaaacc 766

                                                                        
Query: 421  caggacggtcgttggattgtggccatgaacaaatggcaaactctaactgatcttgagctt 480
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 767  caggacggtcgttggattgtggccatgaacaaatggcaaactctaactgatcttgagctt 826

                                                                        
Query: 481  aatgctgacactttcagagaattgaggaaatatacaaatgagtttctaattcacgctgca 540
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 827  aatgctgacactttcagagaattgaggaaatatacaaatgagtttctaattcacgctgca 886

                                                                        
Query: 541  gacgttgaaggtttgtgtggtggtatcgatgaattattggtttctaagcttttcgaatgg 600
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 887  gacgttgaaggtttgtgtggtggtatcgatgaattattggtttctaagcttttcgaatgg 946

                                                                        
Query: 601  accaaagattacgatgatttgaaaatcgtttatgctggtggggccaaaagtgttgatgat 660
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 947  accaaagattacgatgatttgaaaatcgtttatgctggtggggccaaaagtgttgatgat 1006

                                                                        
Query: 661  ttgaaattagtagacgaactaagtcacggaaaagtagatttgacattcggtagttcctta 720
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 1007 ttgaaattagtagacgaactaagtcacggaaaagtagatttgacattcggtagttcctta 1066

                                                                        
Query: 721  gatatatttggtggtaacctagttaagtttgaagactgctgtagatggaatgaaaagcaa 780
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 1067 gatatatttggtggtaacctagttaagtttgaagactgctgtagatggaatgaaaagcaa 1126

                  
Query: 781  ggttag 786
            ||||||
Sbjct: 1127 ggttag 1132


>gi|599967|emb|Z46881.1|SC3299 S.cerevisiae chromosome IX cosmid 3299
          Length = 30977

 Score = 1558 bits (786), Expect = 0.0
 Identities = 786/786 (100%)
 Strand = Plus / Minus

                                                                         
Query: 1     atgacgaagtttattggttgtatagacctgcataatggagaggttaaacagattgtaggt 60
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 15988 atgacgaagtttattggttgtatagacctgcataatggagaggttaaacagattgtaggt 15929

                                                                         
Query: 61    ggaacgttaacgagcaaaaaggaggacgttccaaaaactaactttgtatcacaacatcct 120
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 15928 ggaacgttaacgagcaaaaaggaggacgttccaaaaactaactttgtatcacaacatcct 15869

                                                                         
Query: 121   tcttcatattacgctaaactttacaaagacagagatgtccaaggatgtcatgttattaag 180
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 15868 tcttcatattacgctaaactttacaaagacagagatgtccaaggatgtcatgttattaag 15809

                                                                         
Query: 181   ttgggacctaacaatgacgacgctgcacgcgaggcactccaggagtcaccacaatttcta 240
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 15808 ttgggacctaacaatgacgacgctgcacgcgaggcactccaggagtcaccacaatttcta 15749

                                                                         
Query: 241   caagtgggcggaggaattaatgatacgaactgtttggaatggttaaaatgggccagtaaa 300
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 15748 caagtgggcggaggaattaatgatacgaactgtttggaatggttaaaatgggccagtaaa 15689

                                                                         
Query: 301   gtaattgttacgagttggctatttacaaaagagggtcattttcaattaaaaaggttagaa 360
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 15688 gtaattgttacgagttggctatttacaaaagagggtcattttcaattaaaaaggttagaa 15629

                                                                         
Query: 361   agactgacagaactatgtgggaaagaccgcattgttgtagacttaagctgtagaaaaacc 420
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 15628 agactgacagaactatgtgggaaagaccgcattgttgtagacttaagctgtagaaaaacc 15569

                                                                         
Query: 421   caggacggtcgttggattgtggccatgaacaaatggcaaactctaactgatcttgagctt 480
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 15568 caggacggtcgttggattgtggccatgaacaaatggcaaactctaactgatcttgagctt 15509

                                                                         
Query: 481   aatgctgacactttcagagaattgaggaaatatacaaatgagtttctaattcacgctgca 540
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 15508 aatgctgacactttcagagaattgaggaaatatacaaatgagtttctaattcacgctgca 15449

                                                                         
Query: 541   gacgttgaaggtttgtgtggtggtatcgatgaattattggtttctaagcttttcgaatgg 600
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 15448 gacgttgaaggtttgtgtggtggtatcgatgaattattggtttctaagcttttcgaatgg 15389

                                                                         
Query: 601   accaaagattacgatgatttgaaaatcgtttatgctggtggggccaaaagtgttgatgat 660
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 15388 accaaagattacgatgatttgaaaatcgtttatgctggtggggccaaaagtgttgatgat 15329

                                                                         
Query: 661   ttgaaattagtagacgaactaagtcacggaaaagtagatttgacattcggtagttcctta 720
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 15328 ttgaaattagtagacgaactaagtcacggaaaagtagatttgacattcggtagttcctta 15269

                                                                         
Query: 721   gatatatttggtggtaacctagttaagtttgaagactgctgtagatggaatgaaaagcaa 780
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 15268 gatatatttggtggtaacctagttaagtttgaagactgctgtagatggaatgaaaagcaa 15209

                   
Query: 781   ggttag 786
             ||||||
Sbjct: 15208 ggttag 15203


>gi|172212|gb|M27496.1|YSCPOL2RPB Yeast (S.cerevisiae) RNA polymerase II 45 kD subunit (RPB3) gene,
            complete cds
          Length = 4429

 Score = 1558 bits (786), Expect = 0.0
 Identities = 786/786 (100%)
 Strand = Plus / Minus

                                                                        
Query: 1    atgacgaagtttattggttgtatagacctgcataatggagaggttaaacagattgtaggt 60
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 3221 atgacgaagtttattggttgtatagacctgcataatggagaggttaaacagattgtaggt 3162

                                                                        
Query: 61   ggaacgttaacgagcaaaaaggaggacgttccaaaaactaactttgtatcacaacatcct 120
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 3161 ggaacgttaacgagcaaaaaggaggacgttccaaaaactaactttgtatcacaacatcct 3102

                                                                        
Query: 121  tcttcatattacgctaaactttacaaagacagagatgtccaaggatgtcatgttattaag 180
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 3101 tcttcatattacgctaaactttacaaagacagagatgtccaaggatgtcatgttattaag 3042

                                                                        
Query: 181  ttgggacctaacaatgacgacgctgcacgcgaggcactccaggagtcaccacaatttcta 240
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 3041 ttgggacctaacaatgacgacgctgcacgcgaggcactccaggagtcaccacaatttcta 2982

                                                                        
Query: 241  caagtgggcggaggaattaatgatacgaactgtttggaatggttaaaatgggccagtaaa 300
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2981 caagtgggcggaggaattaatgatacgaactgtttggaatggttaaaatgggccagtaaa 2922

                                                                        
Query: 301  gtaattgttacgagttggctatttacaaaagagggtcattttcaattaaaaaggttagaa 360
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2921 gtaattgttacgagttggctatttacaaaagagggtcattttcaattaaaaaggttagaa 2862

                                                                        
Query: 361  agactgacagaactatgtgggaaagaccgcattgttgtagacttaagctgtagaaaaacc 420
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2861 agactgacagaactatgtgggaaagaccgcattgttgtagacttaagctgtagaaaaacc 2802

                                                                        
Query: 421  caggacggtcgttggattgtggccatgaacaaatggcaaactctaactgatcttgagctt 480
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2801 caggacggtcgttggattgtggccatgaacaaatggcaaactctaactgatcttgagctt 2742

                                                                        
Query: 481  aatgctgacactttcagagaattgaggaaatatacaaatgagtttctaattcacgctgca 540
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2741 aatgctgacactttcagagaattgaggaaatatacaaatgagtttctaattcacgctgca 2682

                                                                        
Query: 541  gacgttgaaggtttgtgtggtggtatcgatgaattattggtttctaagcttttcgaatgg 600
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2681 gacgttgaaggtttgtgtggtggtatcgatgaattattggtttctaagcttttcgaatgg 2622

                                                                        
Query: 601  accaaagattacgatgatttgaaaatcgtttatgctggtggggccaaaagtgttgatgat 660
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2621 accaaagattacgatgatttgaaaatcgtttatgctggtggggccaaaagtgttgatgat 2562

                                                                        
Query: 661  ttgaaattagtagacgaactaagtcacggaaaagtagatttgacattcggtagttcctta 720
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2561 ttgaaattagtagacgaactaagtcacggaaaagtagatttgacattcggtagttcctta 2502

                                                                        
Query: 721  gatatatttggtggtaacctagttaagtttgaagactgctgtagatggaatgaaaagcaa 780
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 2501 gatatatttggtggtaacctagttaagtttgaagactgctgtagatggaatgaaaagcaa 2442

                  
Query: 781  ggttag 786
            ||||||
Sbjct: 2441 ggttag 2436


>gi|218538|dbj|D10933.1|YSPMFACR S.pombe map3 gene for M-factor receptor, complete cds
          Length = 3178

 Score = 58.0 bits (29), Expect = 2e-05
 Identities = 32/33 (96%)
 Strand = Plus / Minus

                                             
Query: 520  gagtttctaattcacgctgcagacgttgaaggt 552
            |||||| ||||||||||||||||||||||||||
Sbjct: 2310 gagtttttaattcacgctgcagacgttgaaggt 2278


>gi|1182047|emb|Z69369.1|SPAC3F10 S.pombe chromosome I cosmid c3F10
          Length = 38010

 Score = 58.0 bits (29), Expect = 2e-05
 Identities = 32/33 (96%)
 Strand = Plus / Plus

                                              
Query: 520   gagtttctaattcacgctgcagacgttgaaggt 552
             |||||| ||||||||||||||||||||||||||
Sbjct: 17552 gagtttttaattcacgctgcagacgttgaaggt 17584


>gi|28828213|gb|AC115612.2| Dictyostelium discoideum chromosome 2 map 6245135-6357017 strain AX4,
             complete sequence
          Length = 111882

 Score = 42.1 bits (21), Expect = 1.3
 Identities = 27/29 (93%)
 Strand = Plus / Plus

                                          
Query: 321   atttacaaaagagggtcattttcaattaa 349
             ||||||||||||| |||||||| ||||||
Sbjct: 40065 atttacaaaagagtgtcatttttaattaa 40093


>gi|21541922|gb|AC091563.9| Homo sapiens chromosome 8, clone RP11-760H22, complete sequence
          Length = 204896

 Score = 42.1 bits (21), Expect = 1.3
 Identities = 21/21 (100%)
 Strand = Plus / Minus

                                  
Query: 285   aaaatgggccagtaaagtaat 305
             |||||||||||||||||||||
Sbjct: 22049 aaaatgggccagtaaagtaat 22029


>gi|25004486|emb|AL591478.19| Mouse DNA sequence from clone RP23-140D14 on chromosome 2, complete
              sequence
          Length = 236979

 Score = 42.1 bits (21), Expect = 1.3
 Identities = 21/21 (100%)
 Strand = Plus / Minus

                                   
Query: 275    tggaatggttaaaatgggcca 295
              |||||||||||||||||||||
Sbjct: 195803 tggaatggttaaaatgggcca 195783


>gi|28971755|dbj|AP005624.3| Homo sapiens genomic DNA, chromosome 8q23, clone: KB1367F12, complete
             sequence
          Length = 117520

 Score = 42.1 bits (21), Expect = 1.3
 Identities = 21/21 (100%)
 Strand = Plus / Minus

                                  
Query: 285   aaaatgggccagtaaagtaat 305
             |||||||||||||||||||||
Sbjct: 46148 aaaatgggccagtaaagtaat 46128


>gi|13603463|dbj|AP003504.1| Oryza sativa (japonica cultivar-group) genomic DNA, chromosome 1, PAC
             clone:P0025A05
          Length = 154298

 Score = 42.1 bits (21), Expect = 1.3
 Identities = 21/21 (100%)
 Strand = Plus / Plus

                                  
Query: 716   ccttagatatatttggtggta 736
             |||||||||||||||||||||
Sbjct: 96665 ccttagatatatttggtggta 96685


>gi|25188171|dbj|AP005717.3| Homo sapiens genomic DNA, chromosome 8q23, clone: KB1471A8, complete
              sequence
          Length = 169835

 Score = 42.1 bits (21), Expect = 1.3
 Identities = 21/21 (100%)
 Strand = Plus / Minus

                                   
Query: 285    aaaatgggccagtaaagtaat 305
              |||||||||||||||||||||
Sbjct: 164159 aaaatgggccagtaaagtaat 164139


>gi|18572222|ref|XM_098872.1| Homo sapiens LOC158088 (LOC158088), mRNA
          Length = 1246

 Score = 40.1 bits (20), Expect = 5.0
 Identities = 20/20 (100%)
 Strand = Plus / Plus

                               
Query: 724 atatttggtggtaacctagt 743
           ||||||||||||||||||||
Sbjct: 695 atatttggtggtaacctagt 714


>gi|15638734|gb|AC092593.2| Homo sapiens BAC clone RP11-68D16 from 4, complete sequence
          Length = 128255

 Score = 40.1 bits (20), Expect = 5.0
 Identities = 20/20 (100%)
 Strand = Plus / Plus

                                 
Query: 653   ttgatgatttgaaattagta 672
             ||||||||||||||||||||
Sbjct: 99263 ttgatgatttgaaattagta 99282


>gi|28270119|emb|AL935253.1| Lactobacillus plantarum strain WCFS1 complete genome; segment 2/11
          Length = 324050

 Score = 40.1 bits (20), Expect = 5.0
 Identities = 20/20 (100%)
 Strand = Plus / Plus

                                 
Query: 560   gtggtatcgatgaattattg 579
             ||||||||||||||||||||
Sbjct: 24705 gtggtatcgatgaattattg 24724


>gi|1495659|emb|X94434.1|LPATOVGNS L.plantarum pln[A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,R,S,T,U,V] genes and
            ORF1
          Length = 16139

 Score = 40.1 bits (20), Expect = 5.0
 Identities = 20/20 (100%)
 Strand = Plus / Plus

                                
Query: 560  gtggtatcgatgaattattg 579
            ||||||||||||||||||||
Sbjct: 2133 gtggtatcgatgaattattg 2152


>gi|8894643|emb|AL109942.13|HSJ473J16 Human DNA sequence from clone RP3-473J16 on chromosome 6q25.3-26
             Contains 3' end of the MAP3K4 (mitogen-activated protein
             kinase kinase kinase 4) gene, a novel mRNA, ESTs, STSs and
             GSSs, complete sequence
          Length = 176217

 Score = 40.1 bits (20), Expect = 5.0
 Identities = 26/28 (92%)
 Strand = Plus / Plus

                                         
Query: 316   tggctatttacaaaagagggtcattttc 343
             ||||| ||||||||||||| ||||||||
Sbjct: 35121 tggctctttacaaaagaggctcattttc 35148


>gi|15795446|emb|AL450105.17| Human DNA sequence from clone RP11-519C17 on chromosome 9, complete
              sequence
          Length = 161506

 Score = 40.1 bits (20), Expect = 5.0
 Identities = 20/20 (100%)
 Strand = Plus / Minus

                                  
Query: 724    atatttggtggtaacctagt 743
              ||||||||||||||||||||
Sbjct: 122273 atatttggtggtaacctagt 122254


>gi|11414487|emb|AL157877.11| Human DNA sequence from clone RP11-2P5 on chromosome 13, complete
             sequence
          Length = 198567

 Score = 40.1 bits (20), Expect = 5.0
 Identities = 23/24 (95%)
 Strand = Plus / Minus

                                     
Query: 322   tttacaaaagagggtcattttcaa 345
             |||| |||||||||||||||||||
Sbjct: 78162 tttaaaaaagagggtcattttcaa 78139


>gi|3845417|gb|AC004837.1|AC004837 Homo sapiens PAC clone RP4-570D2 from 7p13-p14, complete sequence
          Length = 135837

 Score = 40.1 bits (20), Expect = 5.0
 Identities = 23/24 (95%)
 Strand = Plus / Plus

                                     
Query: 145   aaagacagagatgtccaaggatgt 168
             |||||||||||| |||||||||||
Sbjct: 59628 aaagacagagatttccaaggatgt 59651


>gi|2911720|gb|AC004226.1|AC004226 Homo sapiens chromosome 5, BAC clone 313n8 (LBNL H146), complete
             sequence
          Length = 108754

 Score = 40.1 bits (20), Expect = 5.0
 Identities = 23/24 (95%)
 Strand = Plus / Plus

                                     
Query: 714   ttccttagatatatttggtggtaa 737
             ||||| ||||||||||||||||||
Sbjct: 31395 ttcctaagatatatttggtggtaa 31418


>gi|21212599|emb|AL732402.5| Mouse DNA sequence from clone RP23-402I13 on chromosome 11, complete
             sequence
          Length = 103449

 Score = 40.1 bits (20), Expect = 5.0
 Identities = 20/20 (100%)
 Strand = Plus / Minus

                                 
Query: 42    ggttaaacagattgtaggtg 61
             ||||||||||||||||||||
Sbjct: 93735 ggttaaacagattgtaggtg 93716


>gi|10436870|dbj|AK024561.1| Homo sapiens cDNA: FLJ20908 fis, clone ADSE00417
          Length = 1263

 Score = 40.1 bits (20), Expect = 5.0
 Identities = 20/20 (100%)
 Strand = Plus / Plus

                               
Query: 724 atatttggtggtaacctagt 743
           ||||||||||||||||||||
Sbjct: 695 atatttggtggtaacctagt 714


  Database: All GenBank+EMBL+DDBJ+PDB sequences (but no EST, STS, GSS,
  or phase 0, 1 or 2 HTGS sequences)
    Posted date:  Mar 20, 2003 10:39 PM
  Number of letters in database: -658,021,059
  Number of sequences in database:  1,707,549
  
Lambda     K      H
    1.37    0.711     1.31 

Gapped
Lambda     K      H
    1.37    0.711     1.31 


Matrix: blastn matrix:1 -3
Gap Penalties: Existence: 5, Extension: 2
Number of Hits to DB: 3,342,380
Number of Sequences: 1707549
Number of extensions: 3342380
Number of successful extensions: 65744
Number of sequences better than 10.0: 22
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 65699
Number of HSP's gapped (non-prelim): 45
length of query: 786
length of database: 7,931,913,529
effective HSP length: 22
effective length of query: 764
effective length of database: 7,894,347,451
effective search space: 6031281452564
effective search space used: 6031281452564
T: 0
A: 0
X1: 6 (11.9 bits)
X2: 15 (29.7 bits)
S1: 12 (24.3 bits)
S2: 20 (40.1 bits)






 
BLASTX 2.2.5 [Nov-16-2002]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.
RID: 1048254410-02904-28014
Query= ORFN:YIL020C HIS6 SGDID:S0001282, Chr IX from 314033-314818,
reverse complement
         (786 letters)

Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF 
           1,376,251 sequences; 442,128,549 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|6322169|ref|NP_012244.1| phosphoribosyl-5-amino-1-phosphoribo...   543   e-153
gi|10444341|gb|AAG17873.1|AF290199_1 5-proFAR isomerase [Candida...   286   2e-76
gi|19114853|ref|NP_593941.1| probable phosphoribosylformimino-5-...   268   5e-71
gi|28917736|gb|EAA27427.1| hypothetical protein [Neurospora crassa]   268   5e-71
gi|15227607|ref|NP_181165.1| phosphoribosylformimino-5-aminoimid...   205   5e-52
gi|15669727|ref|NP_248540.1| phosphoribosylformimino-5-aminoimid...    67   2e-10
gi|20093802|ref|NP_613649.1| Phosphoribosylformimino-5-aminoimid...    50   3e-05
gi|15792906|ref|NP_282729.1| phosphoribosylformimino-5-aminoimid...    50   5e-05
gi|23122646|gb|ZP_00104781.1| hypothetical protein [Prochlorococ...    49   6e-05
gi|22985724|ref|ZP_00030836.1| hypothetical protein [Burkholderi...    48   1e-04
gi|15678863|ref|NP_275980.1| phosphoribosylformimino-5-aminoimid...    47   4e-04
gi|3913848|sp|O26931|HIS4_METTH 1-(5-phosphoribosyl)-5-[(5-phosp...    47   4e-04
gi|17547666|ref|NP_521068.1| PROBABLE PHOSPHORIBOSYLFORMIMINO-5-...    45   9e-04
gi|123146|sp|P05324|HIS4_METVA 1-(5-phosphoribosyl)-5-[(5-phosph...    44   0.003
gi|123147|sp|P05325|HIS4_METVO 1-(5-phosphoribosyl)-5-[(5-phosph...    42   0.008
gi|22406017|gb|ZP_00000876.1| hypothetical protein [Ferroplasma ...    42   0.008
gi|18978034|ref|NP_579391.1| n-(5'-phospho-d-ribosylformimino)-5...    41   0.017
gi|22979623|gb|ZP_00025343.1| hypothetical protein [Ralstonia me...    41   0.022
gi|27366193|ref|NP_761721.1| Phosphoribosylformimino-5-aminoimid...    40   0.038
gi|23112135|gb|ZP_00097662.1| hypothetical protein [Desulfitobac...    40   0.038
gi|28897916|ref|NP_797521.1| phosphoribosylformimino-5-aminoimid...    40   0.049
gi|21399325|ref|NP_655310.1| His_biosynth, Histidine biosynthesi...    39   0.11 
gi|123154|sp|P26721|HIS6_AZOBR Imidazole glycerol phosphate synt...    39   0.11 
gi|15887398|ref|NP_353079.1| AGR_C_63p [Agrobacterium tumefacien...    39   0.11 
gi|23109767|gb|ZP_00095939.1| hypothetical protein [Novosphingob...    38   0.14 
gi|15921753|ref|NP_377422.1| 230aa long hypothetical phosphoribo...    37   0.24 
gi|21242577|ref|NP_642159.1| phosphoribosylformimino-5- aminoimi...    37   0.32 
gi|18976741|ref|NP_578098.1| putative endoglucanase [Pyrococcus ...    35   0.93 
gi|20455019|sp|Q9RPQ4|HIS6_THEET Imidazole glycerol phosphate sy...    35   1.2  
gi|23020792|ref|ZP_00060487.1| hypothetical protein [Clostridium...    35   1.6  
gi|24373629|ref|NP_717672.1| phosphoribosylformimino-5-aminoimid...    35   1.6  
gi|15596654|ref|NP_250148.1| chemotaxis protein CheZ [Pseudomona...    34   2.1  
gi|12644654|sp|Q51434|CHEZ_PSEAE Chemotaxis protein cheZ               34   2.1  
gi|15643795|ref|NP_228843.1| phosphoribosylformimino-5-aminoimid...    34   2.1  
gi|11277584|pir||T46613 chemotaxis protein cheZ [validated] - Ps...    34   2.7  
gi|19113034|ref|NP_596242.1| hypothetical zinc-finger protein [S...    33   3.5  
gi|9955269|pdb|1QO2|A Chain A, Crystal Structure Of N-((5'-Phosp...    33   3.5  
gi|477064|pir||A47754 1-(5-phosphoribosyl)-5-[ (5-phosphoribosyl...    33   3.5  
gi|15794037|ref|NP_283859.1| putative pantoate--beta-alanine lig...    33   4.6  
gi|20455018|sp|Q9RDX2|HIS6_LEGPN Imidazole glycerol phosphate sy...    33   4.6  
gi|27375764|ref|NP_767293.1| phosphoribosylformino-5-aminoimidaz...    33   6.0  
gi|7484628|pir||T12288 O-succinylhomoserine (thiol)-lyase (EC 4....    33   6.0  
gi|14193302|gb|AAK55887.1|AF267210_2 ATP synthase gamma subunit ...    32   7.9  
gi|15897511|ref|NP_342116.1| Phosphoribosylformimino-5-aminoimid...    32   7.9  
gi|20089116|ref|NP_615191.1| N-(5-phospho-D-ribosylformimino)-5-...    32   7.9  
gi|20086391|dbj|BAB88833.1| axonemal p66.0 [Ciona intestinalis]        32   7.9  

ALIGNMENTS
>gi|6322169|ref|NP_012244.1| phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide
           isomerase; His6p [Saccharomyces cerevisiae]
 gi|731787|sp|P40545|HIS4_YEAST 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase
           (Phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerase)
 gi|1077743|pir||S49962 hypothetical protein YIL020c - yeast (Saccharomyces cerevisiae)
 gi|599979|emb|CAA86972.1| unknown [Saccharomyces cerevisiae]
 gi|2584817|emb|CAA60779.1| N-(5'-phospho-D-ribosylformimino)-5-
           amino-1-(5''-phosphoribosyl)-4-imidazole carboxamide
           isomerase [Saccharomyces cerevisiae]
          Length = 261

 Score =  543 bits (1399), Expect = e-153
 Identities = 261/261 (100%), Positives = 261/261 (100%)
 Frame = +1

Query: 1   MTKFIGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIK 180
           MTKFIGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIK
Sbjct: 1   MTKFIGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIK 60

Query: 181 LGPNNDDAAREALQESPQFLQVGGGINDTNCLEWLKWASKVIVTSWLFTKEGHFQLKRLE 360
           LGPNNDDAAREALQESPQFLQVGGGINDTNCLEWLKWASKVIVTSWLFTKEGHFQLKRLE
Sbjct: 61  LGPNNDDAAREALQESPQFLQVGGGINDTNCLEWLKWASKVIVTSWLFTKEGHFQLKRLE 120

Query: 361 RLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFLIHAA 540
           RLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFLIHAA
Sbjct: 121 RLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFLIHAA 180

Query: 541 DVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKVDLTFGSSL 720
           DVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKVDLTFGSSL
Sbjct: 181 DVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKVDLTFGSSL 240

Query: 721 DIFGGNLVKFEDCCRWNEKQG 783
           DIFGGNLVKFEDCCRWNEKQG
Sbjct: 241 DIFGGNLVKFEDCCRWNEKQG 261


>gi|10444341|gb|AAG17873.1|AF290199_1 5-proFAR isomerase [Candida albicans]
          Length = 279

 Score =  286 bits (733), Expect = 2e-76
 Identities = 158/273 (57%), Positives = 194/273 (71%), Gaps = 15/273 (5%)
 Frame = +1

Query: 1   MTKFIGCIDLHNGEVKQIVGGTLT-----SKKEDVPKTNFVSQHPSSYYAKLYKDRDVQG 165
           MTKF GCID+H+G+VKQIVGGTLT     S K    K NFVS  PSS+YA+LYKD +V+G
Sbjct: 1   MTKFRGCIDIHSGQVKQIVGGTLTQDDSASSKTSSAKENFVSTKPSSHYAQLYKDYNVKG 60

Query: 166 CHVIKLGPN--NDDAAREALQESPQFLQVGGGINDTNCLEWL-KWASKVIVTSWLFTKEG 336
           CHVIKLG N  NDDAA+ AL   P  LQVGGGIN  N   WL + AS VI+TSWLFTK  
Sbjct: 61  CHVIKLGSNPANDDAAKLALSTWPHNLQVGGGINLDNAQYWLDQGASHVILTSWLFTKNE 120

Query: 337 HFQLK----RLERLTELCGKDRIVVDLSCRKT-QDGR--WIVAMNKWQTLTDLELNADTF 495
             +++    +L  +++L GK++++VDLSCR   ++G+  W VAMNKWQT+TD  L+A+  
Sbjct: 121 QDKMELDFGKLREISKLIGKEKLIVDLSCRTVIENGKTNWYVAMNKWQTITDTILSAEFL 180

Query: 496 RELRKYTNEFLIHAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVD 675
            ++  Y +EFLIHAADVEGLC GIDE LV  L EW     + KIVYAGGAKS++DL  V 
Sbjct: 181 LKVSAYCDEFLIHAADVEGLCKGIDEKLVENLGEWCPVGFEEKIVYAGGAKSINDLDTVA 240

Query: 676 ELSHGKVDLTFGSSLDIFGGNLVKFEDCCRWNE 774
           +LS GKVDLT+GSSLDIF G LV F D   WN+
Sbjct: 241 KLSKGKVDLTYGSSLDIFSGKLVNFTDLVEWNK 273


>gi|19114853|ref|NP_593941.1| probable phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotideisomerase (EC 5.3.1.16) [Schizosaccharomyces
           pombe]
 gi|1723254|sp|Q10184|HIS4_SCHPO Probable 1-(5-phosphoribosyl)-5-[(5-
           phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase
           (Phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerase)
 gi|7492826|pir||T38710 probable phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerasesby map position, may be his6 -
           fission yeast (Schizosaccharomyces pombe)
 gi|1182056|emb|CAA93307.1| putative phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerase; fourth step in the histidine
           biosynthetic pathway; similar to S. cerevisiae HIS6
           [Schizosaccharomyces pombe]
          Length = 264

 Score =  268 bits (686), Expect = 5e-71
 Identities = 145/259 (55%), Positives = 182/259 (70%), Gaps = 1/259 (0%)
 Frame = +1

Query: 4   TKFIGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKL 183
           T F  CID+H G+VKQIVGGTL +  +   KTN+VS  PSSYYA+LYK   ++G HVI L
Sbjct: 7   TLFRPCIDIHQGQVKQIVGGTLGNDAD--VKTNYVSLKPSSYYAELYKLNHLEGAHVIML 64

Query: 184 GPNNDDAAREALQESPQFLQVGGGINDTNCLEWLK-WASKVIVTSWLFTKEGHFQLKRLE 360
           GPN ++AA+ AL   P  LQ+GGGIN +N   WL+  ASKVIVTSWLF  +  F L RL+
Sbjct: 65  GPNCEEAAKTALHTWPGALQIGGGINISNAQNWLQEGASKVIVTSWLFP-DAQFDLDRLK 123

Query: 361 RLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFLIHAA 540
            ++   GKDR+VVD+SCR+ +D RW  A+NKWQ +T  ELN +    L +Y +EFLIHAA
Sbjct: 124 AISSKIGKDRLVVDVSCRR-KDNRWFAAINKWQVMTAFELNEENLDLLSQYCSEFLIHAA 182

Query: 541 DVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKVDLTFGSSL 720
           DVEGLC GIDE LV KL EW K    +   YAGG +S++DL LVD+LS GKVDLT GS+L
Sbjct: 183 DVEGLCKGIDEDLVIKLGEWVK----IPTTYAGGGRSIEDLDLVDKLSKGKVDLTIGSAL 238

Query: 721 DIFGGNLVKFEDCCRWNEK 777
           DIFGG +++F     WN +
Sbjct: 239 DIFGG-VLEFTRVVAWNRR 256


>gi|28917736|gb|EAA27427.1| hypothetical protein [Neurospora crassa]
          Length = 257

 Score =  268 bits (686), Expect = 5e-71
 Identities = 141/263 (53%), Positives = 182/263 (69%), Gaps = 3/263 (1%)
 Frame = +1

Query: 1   MTKFIGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIK 180
           MT+F  CIDLH G+VKQIVGGTL S   ++ +TNFVS HP +Y+AKLY+D D+ G HVI 
Sbjct: 1   MTRFRPCIDLHAGQVKQIVGGTLDSATSEL-RTNFVSPHPPAYFAKLYRDNDLSGAHVIM 59

Query: 181 LGPNNDDAAREALQESPQFLQVGGGINDTNCLEWLK-WASKVIVTSWLFTKEGHFQLKRL 357
           LGP N +AA E+L+  P  LQVGGGI D N  EW++  A KVI+TS+LF   G F    L
Sbjct: 60  LGPGNKEAALESLKAWPGGLQVGGGITDANAREWVEAGAEKVIITSYLFPN-GKFSQSHL 118

Query: 358 ER-LTELCG-KDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFLI 531
           +  L  L G K ++V+DLSCR+  D RW VAMNKWQT+TD+E++ ++ + L  Y +EFLI
Sbjct: 119 DAVLAALDGDKSKLVIDLSCRRQGDDRWFVAMNKWQTITDMEVSEESIKALEPYCSEFLI 178

Query: 532 HAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKVDLTFG 711
           HAAD EGL  GIDE LV +L EW      + + YAGG ++++DL+ V  LS GKVDLT G
Sbjct: 179 HAADNEGLQKGIDEKLVQRLSEWC----SIPVTYAGGGRNLEDLETVKRLSGGKVDLTIG 234

Query: 712 SSLDIFGGNLVKFEDCCRWNEKQ 780
           S+LD FGG  V  ++C  WN +Q
Sbjct: 235 SALDCFGGKGVTLQECVEWNRRQ 257


>gi|15227607|ref|NP_181165.1| phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase; protein id: At2g36230.1, supported by cDNA:
           2813., supported by cDNA: gi_3449281 [Arabidopsis
           thaliana]
 gi|11358569|pir||T51822 1-(5-phosphoribosyl)-5-[
           (5-phosphoribosylamino)methylideneamino)imidazole-4-
           carboxam ide isomerase (EC 5.3.1.16) [validated] -
           Arabidopsis thaliana
 gi|3449282|dbj|BAA32456.1| phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase [Arabidopsis thaliana]
 gi|3449284|dbj|BAA32457.1| N'-5'-phosphoribosyl-formimino-5-aminoimidazole- 4-carboxamide
           ribonucleotide isomerase [Arabidopsis thaliana]
 gi|4510353|gb|AAD21442.1| phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase [Arabidopsis thaliana]
 gi|22655218|gb|AAM98199.1| phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase [Arabidopsis thaliana]
 gi|26452338|dbj|BAC43255.1| putative phosphoribosylformimino-5-aminoimidazol e carboxamide
           ribotide isomerase [Arabidopsis thaliana]
 gi|27311893|gb|AAO00912.1| phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase [Arabidopsis thaliana]
          Length = 304

 Score =  205 bits (522), Expect = 5e-52
 Identities = 118/263 (44%), Positives = 167/263 (63%), Gaps = 5/263 (1%)
 Frame = +1

Query: 7   KFIGCIDLHNGEVKQIVGGTLTSKKED--VPKTNFVSQHPSSYYAKLYKDRDVQGCHVIK 180
           +F  CID+H G+VKQIVG TL   KED  V  TNF S   +  YAK+YK+  + G HVI 
Sbjct: 45  QFRPCIDIHKGKVKQIVGSTLRDLKEDGSVLVTNFESDKSAEEYAKMYKEDGLTGGHVIM 104

Query: 181 LG--PNNDDAAREALQESPQFLQVGGGINDTNCLEWL-KWASKVIVTSWLFTKEGHFQLK 351
           LG  P +  AA  AL   P  LQVGGGIN  NC+ ++ + AS VIVTS++F   G   L+
Sbjct: 105 LGADPLSQAAAIGALHAYPGGLQVGGGINSENCMSYIEEGASHVIVTSYVF-NNGKIDLE 163

Query: 352 RLERLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFLI 531
           RL+ +  + GK R+++DLSCRK +DGR+ +  ++WQ  +D+ L+  +   L  +++EFL+
Sbjct: 164 RLKDIVSIVGKQRLILDLSCRK-KDGRYAIVTDRWQKFSDVILDEKSLEFLGGFSDEFLV 222

Query: 532 HAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKVDLTFG 711
           H  DVEG   GIDE LV+ L     +Y  + + YAGG   +DD++ + +   G+VD+T G
Sbjct: 223 HGVDVEGKKLGIDEELVALL----GNYSPIPVTYAGGVTVMDDVERIKDAGKGRVDVTVG 278

Query: 712 SSLDIFGGNLVKFEDCCRWNEKQ 780
           S+LDIFGGNL  ++D   W+ KQ
Sbjct: 279 SALDIFGGNL-PYKDVVAWHHKQ 300


>gi|15669727|ref|NP_248540.1| phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase (hisA1) [Methanococcus jannaschii]
 gi|2842608|sp|Q58927|HIS4_METJA 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase
           (Phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerase)
 gi|2129199|pir||C64491 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase - Methanococcus jannaschii
 gi|1592163|gb|AAB99553.1| phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase (hisA1) [Methanococcus jannaschii]
          Length = 237

 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 63/241 (26%), Positives = 111/241 (46%), Gaps = 5/241 (2%)
 Frame = +1

Query: 13  IGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLGP- 189
           I  +DL + +  Q++ G       D  K +    +P    AK + D   +  H+I L   
Sbjct: 4   IPAVDLKDKKCVQLIQG-------DPNKKHLELNNPVEV-AKKFVDEGAEYLHIIDLDAA 55

Query: 190 ----NNDDAAREALQESPQFLQVGGGINDTNCLEWLKWASKVIVTSWLFTKEGHFQLKRL 357
               NN D  +  ++E    ++VGGGI +   LE  K    + V   +   +   + K +
Sbjct: 56  FGTGNNRDVIKNIIKEVNVPVEVGGGIRN---LEIAKELISLGVDRVIVGTKAILEPKFI 112

Query: 358 ERLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFLIHA 537
           + L +  GKD+IV+ + C++ +     V +  W+   D +   +  +E        L   
Sbjct: 113 DDLNKEIGKDKIVLAVECKEGK-----VVIKGWKEKVD-KTPIEVIKEFEDKVGYILFTN 166

Query: 538 ADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKVDLTFGSS 717
            DVEGL  GI+  ++ +L E T    D+ I+Y+GG  +++D+K + EL  G   +  GS+
Sbjct: 167 VDVEGLLKGINVDIIKELIEKT----DIPIIYSGGITTLEDIKALKEL--GIYGVVIGSA 220

Query: 718 L 720
           L
Sbjct: 221 L 221


>gi|20093802|ref|NP_613649.1| Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide
           (ProFAR) isomerase [Methanopyrus kandleri AV19]
 gi|22095765|sp|Q8TYD6|HIS4_METKA 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase
           (Phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerase)
 gi|19886719|gb|AAM01579.1| Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide
           (ProFAR) isomerase [Methanopyrus kandleri AV19]
          Length = 242

 Score = 50.4 bits (119), Expect = 3e-05
 Identities = 63/245 (25%), Positives = 101/245 (41%), Gaps = 16/245 (6%)
 Frame = +1

Query: 13  IGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHP---SSYYAKLYKDRDVQGCHVIKL 183
           I  +D+  G+  Q+V G       D  +  F S  P   +  +++ +    V      + 
Sbjct: 6   IPSVDVVEGKCVQLVEG-------DPERRTFESDDPVETAHQWSEFFPWIHVVDVDAARG 58

Query: 184 GPNNDDAAREALQESPQFLQVGGGINDTNCLEWL--KWASKVIVTSWLFTKEGHFQLKRL 357
             +N D      +E    +QVGGGI      E L    A ++IV +  FT +  F     
Sbjct: 59  EGDNSDIIGRICEEVDAKVQVGGGIRSAERAEELIELGADRLIVGTVAFTDKDDFS---- 114

Query: 358 ERLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFLIHA 537
            ++ ++C    I V ++    ++   +V+  K      LE   + F E+    + +L  A
Sbjct: 115 -KIVDVCHDHGIEVFVALDVNENHEVLVSGWKEDAGVTLEDAIERFNEV---ADGYLTTA 170

Query: 538 ADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDE-----------LS 684
             VEG   GIDE +V K    T    DL ++YAGG  S+ D+K   E           L 
Sbjct: 171 VHVEGKEMGIDEKVVEKSTGAT----DLPVLYAGGIASIKDVKRAKEAGAYGVVIGTALY 226

Query: 685 HGKVD 699
           HG +D
Sbjct: 227 HGDID 231


>gi|15792906|ref|NP_282729.1| phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase [Campylobacter jejuni]
 gi|20455014|sp|Q9PM74|HIS4_CAMJE 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase
           (Phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerase)
 gi|11270582|pir||G81255 1-(5-phosphoribosyl)-5-[
           (5-phosphoribosylamino)methylideneamino)imidazole-4-
           carboxam ide isomerase (EC 5.3.1.16) Cj1601 [imported] -
           Campylobacter jejuni (strain NCTC 11168)
 gi|6969018|emb|CAB73589.1| phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase [Campylobacter jejuni subsp. jejuni NCTC
           11168]
          Length = 243

 Score = 49.7 bits (117), Expect = 5e-05
 Identities = 64/243 (26%), Positives = 109/243 (44%), Gaps = 11/243 (4%)
 Frame = +1

Query: 1   MTKFIGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIK 180
           MT+ I  +DL +GEV ++V G    KK  V K N + +       K Y+    +  H++ 
Sbjct: 1   MTQIIPALDLIDGEVVRLVKGDYEQKK--VYKYNPLKKF------KEYEKAGAKELHLVD 52

Query: 181 LGPNNDDAARE------ALQESPQFLQVGGGINDTNCLE-WLKWASKVIVTSWLFTKEGH 339
           L    D + R+        +E    LQVGGGI     ++  L    K +V   +  K+  
Sbjct: 53  LTGAKDPSKRQFALIEKLAKEVSVNLQVGGGIRSKEEVKALLDCGVKRVVIGSMAIKDAT 112

Query: 340 FQLKRLERLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTN 519
             L+ L+      G + IV+ L     +D  ++VA+N WQ  +D +L       L  Y+N
Sbjct: 113 LCLEILKEF----GSEAIVLALDTILKED--YVVAVNAWQEASDKKL----MEVLDFYSN 162

Query: 520 EFLIH--AADV--EGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSH 687
           + L H    D+  +G   G++  L   + E    + ++ I  +GG  S+ DL+ +  +  
Sbjct: 163 KGLKHILCTDISKDGTMQGVNVRLYKLIHE---IFPNICIQASGGVASLKDLENLKGICS 219

Query: 688 GKV 696
           G +
Sbjct: 220 GVI 222


>gi|23122646|gb|ZP_00104781.1| hypothetical protein [Prochlorococcus marinus subsp. pastoris str.
           CCMP1378]
          Length = 255

 Score = 49.3 bits (116), Expect = 6e-05
 Identities = 52/230 (22%), Positives = 101/230 (43%), Gaps = 11/230 (4%)
 Frame = +1

Query: 7   KFIGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLG 186
           K I  IDL NG+  ++  G    KK+        S+ P    AK +++   +  H++ L 
Sbjct: 2   KLIPAIDLMNGKCVRLFKGDFNKKKD-------FSREPYE-QAKYWENEGAKCIHIVDLD 53

Query: 187 ------PNNDDAAREALQESPQFLQVGGGINDTNCLEWL--KWASKVIVTSWLFTKEGHF 342
                 P ND + ++ ++     +Q+GGGI     ++ L      KVI+        G  
Sbjct: 54  AAKTGIPTNDQSIQKIVKSVNIPIQIGGGIRSLERIKQLFSYGVDKVIM--------GTS 105

Query: 343 QLKRLERLTELCGK--DRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKY- 513
            ++  E +  L  K   RI++ +  ++ +     V+   W   +D+ L  +  +E   + 
Sbjct: 106 AIENKELVKSLSTKFPSRIIIGIDAKEGK-----VSTRGWLKQSDV-LATELVQEFSSFK 159

Query: 514 TNEFLIHAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDL 663
              F++   + +G   G +E+ + K+ E T    D+ ++ +GG  S+ DL
Sbjct: 160 IASFIVTDINTDGTLEGTNEVFIKKILEIT----DIPVIASGGVGSISDL 205


>gi|22985724|ref|ZP_00030836.1| hypothetical protein [Burkholderia fungorum]
          Length = 250

 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 62/235 (26%), Positives = 108/235 (45%), Gaps = 12/235 (5%)
 Frame = +1

Query: 13  IGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLG-- 186
           I  IDL +G+  ++       K+ D+ +    S+ P++  A+ + DR  +  H++ L   
Sbjct: 4   IPAIDLKDGQCVRL-------KQGDMDQATIFSEEPAAM-ARHWVDRGARRLHLVDLNGA 55

Query: 187 ----PNNDDAAREALQESPQFL--QVGGGINDTNCLEWL--KWASKVIVTSWLFTKEGHF 342
               P N+DA R  + E    +  Q+GGGI D N +E       S VI+ +      G  
Sbjct: 56  FAGKPKNEDAIRAIIAEVGGEIPVQLGGGIRDLNTIERYLDDGLSYVIIGTAAVKNPGFL 115

Query: 343 QLKRLERLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNE 522
           Q    +  T   G   I+V L  +   DG+  VA + W  LT  E+ AD  R+   Y  E
Sbjct: 116 Q----DACTAFGG--HIIVGLDAK---DGK--VATDGWSKLTGHEV-ADLARKFEDYGCE 163

Query: 523 FLIHAADV--EGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDEL 681
            +I+  D+  +G+  GI+     +L    K    + ++ +GG  ++ D++ + E+
Sbjct: 164 SIIY-TDIGRDGMLQGINIEATVRLARAVK----IPVIASGGLSNLADIESLCEV 213


>gi|15678863|ref|NP_275980.1| phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase [Methanothermobacter thermautotrophicus]
 gi|7437380|pir||E69212 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase - Methanobacterium thermoautotrophicum
           (strain Delta H)
 gi|2621934|gb|AAB85341.1| phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase [Methanothermobacter thermautotrophicus str.
           Delta H]
          Length = 288

 Score = 46.6 bits (109), Expect = 4e-04
 Identities = 54/244 (22%), Positives = 98/244 (40%), Gaps = 8/244 (3%)
 Frame = +1

Query: 13  IGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLG-- 186
           I  +D+ +G+  Q+V G         P T  V     +  A  ++    +  HV+ L   
Sbjct: 53  IPAVDIKDGKCVQLVQGK--------PGTEQVVLDDPAGVAGRWESLGAETIHVVDLDGA 104

Query: 187 ---PNNDDAAREALQESPQFLQVGGGINDTNCLEWLKWASKVIVTSWLFTKEGHFQLKRL 357
                N    +E  +     LQ+GGGI         ++A K++   +     G   ++  
Sbjct: 105 LGLEKNTGILKEITERVSVPLQIGGGIRSR------EYAGKLLDMGFERVILGTMAIENP 158

Query: 358 ERLTELCGK---DRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFL 528
             + EL G+   +RI+V L  R ++     V +  W             +   +     L
Sbjct: 159 AIVEELAGEYGSERIMVSLDSRDSR-----VVIRGWTEKVPFTAEEMARKFQERGAGSIL 213

Query: 529 IHAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKVDLTF 708
               D EGL  G D   VS+L E      ++ ++Y+GG  S++DL+++     G + +  
Sbjct: 214 FTNVDFEGLLSGFDLKPVSELVEAV----EIPVIYSGGVSSLNDLRMLQ--GTGVMGVVI 267

Query: 709 GSSL 720
           GS++
Sbjct: 268 GSAI 271


>gi|3913848|sp|O26931|HIS4_METTH 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase
           (Phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerase)
          Length = 239

 Score = 46.6 bits (109), Expect = 4e-04
 Identities = 54/244 (22%), Positives = 98/244 (40%), Gaps = 8/244 (3%)
 Frame = +1

Query: 13  IGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLG-- 186
           I  +D+ +G+  Q+V G         P T  V     +  A  ++    +  HV+ L   
Sbjct: 4   IPAVDIKDGKCVQLVQGK--------PGTEQVVLDDPAGVAGRWESLGAETIHVVDLDGA 55

Query: 187 ---PNNDDAAREALQESPQFLQVGGGINDTNCLEWLKWASKVIVTSWLFTKEGHFQLKRL 357
                N    +E  +     LQ+GGGI         ++A K++   +     G   ++  
Sbjct: 56  LGLEKNTGILKEITERVSVPLQIGGGIRSR------EYAGKLLDMGFERVILGTMAIENP 109

Query: 358 ERLTELCGK---DRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFL 528
             + EL G+   +RI+V L  R ++     V +  W             +   +     L
Sbjct: 110 AIVEELAGEYGSERIMVSLDSRDSR-----VVIRGWTEKVPFTAEEMARKFQERGAGSIL 164

Query: 529 IHAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKVDLTF 708
               D EGL  G D   VS+L E      ++ ++Y+GG  S++DL+++     G + +  
Sbjct: 165 FTNVDFEGLLSGFDLKPVSELVEAV----EIPVIYSGGVSSLNDLRMLQ--GTGVMGVVI 218

Query: 709 GSSL 720
           GS++
Sbjct: 219 GSAI 222


>gi|17547666|ref|NP_521068.1| PROBABLE PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE
           RIBOTIDE ISOMERASE PROTEIN [Ralstonia solanacearum]
 gi|20454962|sp|Q8XV84|HIS4_RALSO 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase
           (Phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerase)
 gi|17429970|emb|CAD16654.1| PROBABLE PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE
           RIBOTIDE ISOMERASE PROTEIN [Ralstonia solanacearum]
          Length = 247

 Score = 45.4 bits (106), Expect = 9e-04
 Identities = 62/229 (27%), Positives = 105/229 (45%), Gaps = 12/229 (5%)
 Frame = +1

Query: 13  IGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLG-- 186
           I  IDL +G+  ++       K+ D+ +    S+ P++  A+ + D+  +  H++ L   
Sbjct: 4   IPAIDLKDGQCVRL-------KQGDMDQATVFSEDPAAM-ARHWVDQGARRLHLVDLNGA 55

Query: 187 ----PNNDDAAREALQE--SPQFLQVGGGINDTNCLE-WL-KWASKVIVTSWLFTKEGHF 342
               P N+ A +  + E  S   +Q+GGGI D N +E WL    S VI+ +      G  
Sbjct: 56  FVGKPRNEAAIKAIIAEVGSEIPVQLGGGIRDLNTIERWLDDGLSYVIIGTAAVKNPGFL 115

Query: 343 QLKRLERLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNE 522
           Q    +  T   G   I+V L  R   DG+  VA + W  LT  E+  D  R+   Y  E
Sbjct: 116 Q----DACTAFGG--HIIVGLDAR---DGK--VATDGWSKLTGHEV-VDLARKYEDYGVE 163

Query: 523 FLIHAADV--EGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDL 663
            +I+  D+  +G+  GI+     KL +       + ++ +GG  S+ D+
Sbjct: 164 SIIY-TDIGRDGMLQGINIDATVKLAQSV----SIPVIASGGLSSLKDI 207


>gi|123146|sp|P05324|HIS4_METVA 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase
           (Phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerase)
 gi|11270572|pir||T48888 probable phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerase [imported] - Methanococcus vannielii
 gi|150050|gb|AAA72490.1| hisA protein
          Length = 238

 Score = 43.9 bits (102), Expect = 0.003
 Identities = 58/245 (23%), Positives = 100/245 (40%), Gaps = 9/245 (3%)
 Frame = +1

Query: 13  IGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLGPN 192
           I  +D+ N +  Q++ G         P    V        AK + ++  +  H++ L   
Sbjct: 4   IPAVDMKNKKCVQLIQGN--------PDKKHVELDNPPEIAKKWVEQGAEMLHLVNLDGA 55

Query: 193 ------NDDAAREALQESPQFLQVGGGINDTNCLEWL--KWASKVIVTSWLFTKEGHFQL 348
                 ND+   E ++ S   +Q+GGGI   +   +   K A KVI+ +           
Sbjct: 56  INGKRVNDEFIEETIKNSGVPVQIGGGIRSVSDALYFIEKGAEKVILGTVAIQNP----- 110

Query: 349 KRLERLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLE-LNADTFRELRKYTNEF 525
           K +  ++ + GK+++ V L  +   DG+  V +  W   TD   +      E        
Sbjct: 111 KIVREISSIVGKEKVTVALDAK---DGK--VLIKGWTEKTDYSPVQIGKILE-NMGAGSI 164

Query: 526 LIHAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKVDLT 705
           L    D EGL  GI+ L   +L     D  ++ I+ +GG  +V+DL    E+  G   + 
Sbjct: 165 LFTNVDSEGLLEGINVLPTKELV----DNLNIPIIASGGVTTVEDLLKFKEI--GVYAVV 218

Query: 706 FGSSL 720
            GS+L
Sbjct: 219 VGSAL 223


>gi|123147|sp|P05325|HIS4_METVO 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase
           (Phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerase)
 gi|11270570|pir||T48887 probable phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerase [imported] - Methanococcus voltae
 gi|150048|gb|AAA72489.1| hisA protein
          Length = 242

 Score = 42.4 bits (98), Expect = 0.008
 Identities = 57/245 (23%), Positives = 107/245 (43%), Gaps = 9/245 (3%)
 Frame = +1

Query: 13  IGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLGPN 192
           I  +D+  G+  Q++ G  T +  +    + +        AK++ +   +  H++ L   
Sbjct: 4   IPAVDMKEGKCVQLIQGDPTKRHVEYDNPDEI--------AKMWIENGAEMLHLVDLDGA 55

Query: 193 NDD------AAREALQESPQFLQVGGGINDTNCLEWL--KWASKVIVTSWLFTKEGHFQL 348
            D         ++ +QES   +Q+GGGI     +E L     +KVI+ + +  +   F  
Sbjct: 56  IDGERVNLPCVKKIIQESKVPVQMGGGIRTIQDVEELVDLGINKVIIGT-VAVQNPDF-- 112

Query: 349 KRLERLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTD-LELNADTFRELRKYTNEF 525
             +E+L +  G D+I+V L  +   DG+  V +  W+  T+   +      E  K     
Sbjct: 113 --VEQLAKKVGSDKIMVALDAK---DGK--VVIKGWKEKTEYTPVQMGKILE-EKGAGSI 164

Query: 526 LIHAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKVDLT 705
           L    D EGL  GI+     +L     D  ++ I+ +GG  +++D  L++    G   + 
Sbjct: 165 LFTNVDSEGLLNGINITPTKELV----DNLNIPIIASGGVTTIED--LIEFKKIGVAGVV 218

Query: 706 FGSSL 720
            GS+L
Sbjct: 219 VGSAL 223


>gi|22406017|gb|ZP_00000876.1| hypothetical protein [Ferroplasma acidarmanus]
          Length = 229

 Score = 42.4 bits (98), Expect = 0.008
 Identities = 59/257 (22%), Positives = 97/257 (37%), Gaps = 6/257 (2%)
 Frame = +1

Query: 22  IDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLG----- 186
           ID++NGE   +  G +   +       F +Q  SS   KL         H++ L      
Sbjct: 8   IDIYNGEAVSLENGKIEKIESFGDPVKF-AQEFSSISGKL---------HIVDLNGAFTG 57

Query: 187 -PNNDDAAREALQESPQFLQVGGGINDTNCLEWLKWASKVIVTSWLFTKEGHFQLKRLER 363
            P N +  +   +    F+Q GGG      +E    A   +    +         K LE 
Sbjct: 58  NPANTNLIKNIRKNVKSFMQAGGGYRTMESIE----AGYSLGIDSIIIGTASLDKKILEE 113

Query: 364 LTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFLIHAAD 543
           ++E      I +D            +  N W   T++    D +  ++   N F+  A +
Sbjct: 114 VSEKHKNITISIDAY-------NGYIKYNGWADGTEISYR-DFYSMVKGRANRFIFTAIN 165

Query: 544 VEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKVDLTFGSSLD 723
            +G  G I  +         K +D+   +YAGG  S+DDLK ++ +  G      G +L 
Sbjct: 166 SDGT-GHISRI--------EKFWDEGYFMYAGGVNSIDDLKKLENM--GFNGAIIGKAL- 213

Query: 724 IFGGNLVKFEDCCRWNE 774
            + GN+   E  C  NE
Sbjct: 214 -YNGNIKIEELKCLQNE 229


>gi|18978034|ref|NP_579391.1| n-(5'-phospho-d-ribosylformimino)-5-amino-1-
           (5''-phosphoribosyl)-4-imidazolecarboxamide isomerase
           [Pyrococcus furiosus DSM 3638]
 gi|20454952|sp|P58791|HIS4_PYRFU 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase
           (Phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerase)
 gi|18893819|gb|AAL81786.1| n-(5'-phospho-d-ribosylformimino)-5-amino-1-
           (5''-phosphoribosyl)-4-imidazolecarboxamide isomerase
           [Pyrococcus furiosus DSM 3638]
          Length = 240

 Score = 41.2 bits (95), Expect = 0.017
 Identities = 53/231 (22%), Positives = 95/231 (41%), Gaps = 6/231 (2%)
 Frame = +1

Query: 22  IDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLG----- 186
           ID+ +G+V ++  G    KK++V     V   P  +  K      V   H++ L      
Sbjct: 9   IDIMDGKVVRLYKG----KKDEVK----VYGDPLKFAEKF--SEYVDKIHIVDLDGAFSG 58

Query: 187 -PNNDDAAREALQESPQFLQVGGGINDTNCLEWLKWASKVIVTSWLFTKEGHFQLKRLER 363
            P N D   + +++    +Q+GGG  D    E +K A  + V + +   +    +  LER
Sbjct: 59  KPQNLDIVEKIIRDVGVRVQIGGGFRD---YESIKKAYDIGVENVIIGTKA-LDISFLER 114

Query: 364 LTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFLIHAAD 543
           +T       + +D    K     WI   +         L  D ++ LRK+ N F+    D
Sbjct: 115 ITSEFEGITVSLDSKGGKIFTKGWIEEESL--------LVEDAYKMLRKFVNRFVYTVID 166

Query: 544 VEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKV 696
            +G   GI+++         + + D + +YAGG  +  D+  + E+    V
Sbjct: 167 RDGTLLGIEKI--------KRFWGDEEFIYAGGVATPTDIIQLAEIGFSGV 209


>gi|22979623|gb|ZP_00025343.1| hypothetical protein [Ralstonia metallidurans]
          Length = 247

 Score = 40.8 bits (94), Expect = 0.022
 Identities = 56/230 (24%), Positives = 101/230 (43%), Gaps = 13/230 (5%)
 Frame = +1

Query: 13  IGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLG-- 186
           I  IDL +G+  ++       K+ D+ +    S+ P++  A+ + ++  +  H++ L   
Sbjct: 4   IPAIDLKDGQCVRL-------KQGDMDQATVFSEDPAAM-ARHWVNQGARRLHLVDLNGA 55

Query: 187 ----PNNDDAAREALQESPQFL--QVGGGINDTNCLE-WLKWASKVIVTSWLFTKEGHFQ 345
               P N+ A +  + E    +  Q+GGGI D N +E WL      ++      K   F 
Sbjct: 56  FVGKPRNEAAIKAIIAEVGDEIPVQLGGGIRDLNTIERWLDDGLSYVIIGTAAVKNPGF- 114

Query: 346 LKRLERLTELCGK--DRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTN 519
                 L + C      I+V L  +   DG+  VA + W  LT  E+ AD  R+   Y  
Sbjct: 115 ------LKDACAAFGGHIIVGLDAK---DGK--VATDGWSKLTGHEV-ADLARKYEDYGV 162

Query: 520 EFLIHAADV--EGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDL 663
           E +I+  D+  +G+  GI+     KL         + ++ +GG  ++ D+
Sbjct: 163 ESIIY-TDIGRDGMLQGINIDATVKLARSM----SIPVIASGGLSNMADI 207


>gi|27366193|ref|NP_761721.1| Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide
           isomerase [Vibrio vulnificus CMCP6]
 gi|27362393|gb|AAO11248.1|AE016806_238 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide
           isomerase [Vibrio vulnificus CMCP6]
          Length = 245

 Score = 40.0 bits (92), Expect = 0.038
 Identities = 48/226 (21%), Positives = 92/226 (40%), Gaps = 8/226 (3%)
 Frame = +1

Query: 13  IGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLGPN 192
           I  +DL  G+V ++  G       D  +       P+  +  LY        H++ L   
Sbjct: 3   IPALDLIEGQVVRLYQG-------DYGQVTEYKVDPAEQF-NLYHQAGANWLHLVDLTGA 54

Query: 193 NDDAAREA------LQESPQFLQVGGGIN-DTNCLEWLKWASKVIVTSWLFTKEGHFQLK 351
            D  AR+       L  +P  +Q+GGG+  + + ++ L+  ++ +V      K+      
Sbjct: 55  KDTTARQLDLIAKLLASTPANIQIGGGVRTEQDVIDLLEAGAQRVVVGSTAVKQPELVKG 114

Query: 352 RLERLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFLI 531
            +E+     G ++IV+ L     QDG   VA++ WQ  + + + A     +  Y    L 
Sbjct: 115 WMEKY----GAEKIVLALDINIDQDGTRKVAISGWQEDSGVTIEA----LINDYLTVGLQ 166

Query: 532 HAADVE-GLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLK 666
           H    +    G ++   V    +  K Y  ++   +GG  S+ D++
Sbjct: 167 HVLCTDISRDGTLEGSNVELYVDLCKQYPQVQFQSSGGIGSLTDIE 212


>gi|23112135|gb|ZP_00097662.1| hypothetical protein [Desulfitobacterium hafniense]
          Length = 250

 Score = 40.0 bits (92), Expect = 0.038
 Identities = 51/234 (21%), Positives = 98/234 (41%), Gaps = 7/234 (2%)
 Frame = +1

Query: 22  IDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLG----- 186
           IDL  G+  +++ G +    ED        + P    A+ +K++     HV+ L      
Sbjct: 9   IDLKEGKAVRLLQGRM----EDA---TVYGEQPVEV-ARKFKEQGADSLHVVDLDGAFAG 60

Query: 187 -PNNDDAAREALQESPQFLQVGGGINDTNCL-EWLKWASKVIVTSWLFTKEGHFQLKRLE 360
            P ND    + +Q S   +QVGGGI     + E LK   + ++   +  +      K ++
Sbjct: 61  KPVNDAVILKLIQSSGLRVQVGGGIRTLERIEELLKLGVERVILGTVAVRNPELVEKAVQ 120

Query: 361 RLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFLIHAA 540
           R  E      +V+ +  +   DG  +VA+  W   T+++      R  +      +    
Sbjct: 121 RFEE-----AVVIGIDAK---DG--LVAVQGWAEKTEIKALDLALRMKKVGVKHLVFTDI 170

Query: 541 DVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKVDL 702
             +G+  G +   +    E  +    L++V +GG   ++DL+L+ E ++  V L
Sbjct: 171 SRDGMLQGPN---IQSTVELAR-LSGLQVVASGGVSRLEDLRLLQEEANRGVSL 220


>gi|28897916|ref|NP_797521.1| phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase [Vibrio parahaemolyticus RIMD 2210633]
 gi|28806130|dbj|BAC59405.1| phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase [Vibrio parahaemolyticus]
          Length = 245

 Score = 39.7 bits (91), Expect = 0.049
 Identities = 48/226 (21%), Positives = 93/226 (41%), Gaps = 8/226 (3%)
 Frame = +1

Query: 13  IGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLGPN 192
           I  +DL  G+V ++  G       D  +       P+  +  LY        H++ L   
Sbjct: 3   IPALDLIEGQVVRLYQG-------DYGQVTEYKVDPAEQF-NLYHQAGADWLHLVDLTGA 54

Query: 193 NDDAAREA------LQESPQFLQVGGGIN-DTNCLEWLKWASKVIVTSWLFTKEGHFQLK 351
            D +AR+       L  +P  +Q+GGG+  + + ++ L+  ++ +V      K+      
Sbjct: 55  KDTSARQLDLIAKLLASTPANIQIGGGVRTEQDVVDLLEAGAQRVVVGSTAVKQPELVKG 114

Query: 352 RLERLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFLI 531
            +E+     G ++IV+ L     QDG   VA++ WQ  + + + A     +  Y    L 
Sbjct: 115 WMEKY----GAEKIVLALDINIDQDGTRKVAISGWQEDSGVTIEA----LINDYLTVGLQ 166

Query: 532 HAADVE-GLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLK 666
           H    +    G ++   V    +  K Y  ++   +GG  S+ D++
Sbjct: 167 HVLCTDISRDGTLEGSNVELYVDLCKQYPQVQFQSSGGIGSLADIE 212


>gi|21399325|ref|NP_655310.1| His_biosynth, Histidine biosynthesis protein [Bacillus anthracis
           A2012]
          Length = 252

 Score = 38.5 bits (88), Expect = 0.11
 Identities = 39/167 (23%), Positives = 68/167 (40%), Gaps = 2/167 (1%)
 Frame = +1

Query: 238 LQVGGGINDTNCLEWL--KWASKVIVTSWLFTKEGHFQLKRLERLTELCGKDRIVVDLSC 411
           L VGGGI+    +  L    A KV + S           K +E   +  G   IVV +  
Sbjct: 77  LTVGGGISSVKDMYNLLRAGADKVSINSAAVRNP-----KLIEEGAQHFGSQCIVVAIDA 131

Query: 412 RKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFLIHAADVEGLCGGIDELLVSKL 591
           RK  +G+W V +N  +  T ++      R +     E L+ + D +G   G D  L  ++
Sbjct: 132 RKVAEGKWNVYVNGGRVDTGMDAIGWAKRVVMLGAGEILLTSMDADGTKNGYDLRLTEEI 191

Query: 592 FEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKVDLTFGSSLDIFG 732
            +       + ++ +GG    D   +++      VD    +S+  +G
Sbjct: 192 SKSV----SIPVIASGGCGHAD--HIIEVFQKTTVDAALAASIFHYG 232


>gi|123154|sp|P26721|HIS6_AZOBR Imidazole glycerol phosphate synthase subunit hisF (IGP synthase
           cyclase subunit) (IGP synthase subunit hisF) (ImGP
           synthase subunit hisF) (IGPS subunit hisF)
 gi|77534|pir||S16802 cyclase hisF - Azospirillum brasilense
 gi|38674|emb|CAA43519.1| cyclase [Azospirillum brasilense]
          Length = 261

 Score = 38.5 bits (88), Expect = 0.11
 Identities = 39/181 (21%), Positives = 75/181 (41%), Gaps = 3/181 (1%)
 Frame = +1

Query: 199 DAAREALQESPQFLQVGGGINDTNCLE--WLKWASKVIVTSWLFTKEGHFQLKRLERLTE 372
           D  R   ++    L VGGG+   + +    L  A KV + +    +    Q        E
Sbjct: 64  DVVRRTAEQVFMPLTVGGGVRTVDDIRKLLLAGADKVSINTAAIHRPEFVQ-----EAAE 118

Query: 373 LCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKY-TNEFLIHAADVE 549
             G   IVV +  ++ + GRW +  +  +  T ++   +  + +  Y   E L+ + D +
Sbjct: 119 KFGAQCIVVAIDAKQVEPGRWEIFTHGGRKATGIDA-IEWAKRMESYGAGEILLTSMDRD 177

Query: 550 GLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKVDLTFGSSLDIF 729
           G   G D  L  K+ +  +    + ++ +GG  ++D   LV+ +  G       +S+  F
Sbjct: 178 GTKSGFDLALTRKVADGLR----IPVIASGGVGTLD--HLVEGIREGHATAVLAASIFHF 231

Query: 730 G 732
           G
Sbjct: 232 G 232


>gi|15887398|ref|NP_353079.1| AGR_C_63p [Agrobacterium tumefaciens]
 gi|17933965|ref|NP_530755.1| phosphoribosylformino-5-aminoimidazole carboxamide ribotide
           isomerase [Agrobacterium tumefaciens str. C58 (U.
           Washington)]
 gi|20454951|sp|P58790|HIS4_AGRT5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase
           (Phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerase)
 gi|25292636|pir||G97363 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase [imported] - Agrobacterium tumefaciens
           (strain C58, Cereon)
 gi|25292637|pir||AI2581 hypothetical protein hisA [imported] - Agrobacterium tumefaciens
           (strain C58, Dupont)
 gi|15154903|gb|AAK85864.1| AGR_C_63p [Agrobacterium tumefaciens str. C58 (Cereon)]
 gi|17738359|gb|AAL41071.1| phosphoribosylformino-5-aminoimidazole carboxamide ribotide
           isomerase [Agrobacterium tumefaciens str. C58 (U.
           Washington)]
          Length = 247

 Score = 38.5 bits (88), Expect = 0.11
 Identities = 50/221 (22%), Positives = 94/221 (42%), Gaps = 6/221 (2%)
 Frame = +1

Query: 22  IDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKL-----G 186
           IDL +GE  ++       K  D+ +    ++ P +  AK ++D+  +  HV+ L     G
Sbjct: 7   IDLKDGECVRL-------KLGDMEQATVYNEDPGAQ-AKAFEDQGFEWLHVVDLNGAFAG 58

Query: 187 PNNDDAAREALQESPQF-LQVGGGINDTNCLEWLKWASKVIVTSWLFTKEGHFQLKRLER 363
              + AA +A+ +S +  +Q+GGGI   + +E   W S+ +    L T      +  +E 
Sbjct: 59  ETVNGAAVDAILKSTKNPVQLGGGIRTLDHIE--AWLSRGLARVILGTVAVRDPVLVIEA 116

Query: 364 LTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFLIHAAD 543
                G+  + +D    K       VA+  W   ++L +     R         +    D
Sbjct: 117 CKRFPGQVAVGIDAKGGK-------VAVEGWAEASELGIIELAKRFEGAGVAAIIYTDID 169

Query: 544 VEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLK 666
            +G+  GI+     +L     D   + ++ +GG  S+DD+K
Sbjct: 170 RDGILAGINWASTLEL----ADAVSIPVIASGGLASIDDIK 206


>gi|23109767|gb|ZP_00095939.1| hypothetical protein [Novosphingobium aromaticivorans]
          Length = 277

 Score = 38.1 bits (87), Expect = 0.14
 Identities = 50/224 (22%), Positives = 91/224 (40%), Gaps = 7/224 (3%)
 Frame = +1

Query: 22  IDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLGPN--- 192
           IDL  G+V ++  G       D+ +      +P+ + A L+     Q  HV+ L  +   
Sbjct: 43  IDLKAGQVVRLAEG-------DMDRATVYGDNPA-HQASLFAQAGSQYLHVVDLDGSFAG 94

Query: 193 ---NDDAAREALQESPQFLQVGGGINDTNCLE-WLKWASKVIVTSWLFTKEGHFQLKRLE 360
              N +A    L+  P  +Q+GGGI     +  W       +V      K+  F +K + 
Sbjct: 95  RAENREAVEGILKSFPGHVQLGGGIRTREAVSGWFDLGVSRVVMGTAALKDPQF-VKDMA 153

Query: 361 RLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFLIHAA 540
           +  E  G   + VD      +DG  +VA   W  ++D+ +     R         L    
Sbjct: 154 K--EFPGGIVVAVD-----ARDG--MVATEGWADVSDVSVVDLARRFEDAGVASLLFTDI 204

Query: 541 DVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLV 672
             +GL  G++     +L        D+ ++ +GG K +DD++++
Sbjct: 205 GRDGLLKGVNLDATVELARRV----DIPVIASGGVKGIDDIRML 244


>gi|15921753|ref|NP_377422.1| 230aa long hypothetical phosphoribosylformimino-5-aminoimidazole
           carboxamide ribotide isomerase [Sulfolobus tokodaii]
 gi|20454985|sp|Q970Z2|HIS4_SULTO 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase
           (Phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerase)
 gi|15622540|dbj|BAB66531.1| 230aa long hypothetical phosphoribosylformimino-5-aminoimidazole
           carboxamide ribotide isomerase [Sulfolobus tokodaii]
          Length = 230

 Score = 37.4 bits (85), Expect = 0.24
 Identities = 59/251 (23%), Positives = 108/251 (43%), Gaps = 13/251 (5%)
 Frame = +1

Query: 1   MTKFIGCIDLHNGE-VKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVI 177
           M K +  ID+  G+ VK+I G         V  +  +  +P     ++Y++      HV+
Sbjct: 1   MLKVVPSIDISEGKAVKRIRG---------VKGSGLILGNPVKIAYEIYEE-GYDYLHVV 50

Query: 178 KLGP-----NNDDAAREALQESPQFLQVGGGINDTNCLE-WLKWASKVIVTSWLFTKEGH 339
            L       NN++  ++  +   +++QVGGGI +    E  L +    IV S L  K+  
Sbjct: 51  DLDSAEENGNNEEYVKDICKIGFKWVQVGGGIRNVEKAERLLDYDCSAIVISTLPIKDP- 109

Query: 340 FQLKRLERLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQ----TLTDLELNADTFRELR 507
              K    + ++ GKD+I++ +      D    V +  W+     + D  L+ D+   + 
Sbjct: 110 ---KSFMDIQKIIGKDKILLSVD----YDSSGYVLIRGWKEKSIKVLDFLLSYDSLGYIF 162

Query: 508 KYTNEFLIHAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDE--L 681
            Y           EG   GID    + +  +      LK  YAGG  S++DL  ++E  +
Sbjct: 163 TYVEN--------EGTKRGID----NNVKNYVIRIKGLK-EYAGGIGSIEDLYKLNEYGI 209

Query: 682 SHGKVDLTFGS 714
           ++  + ++F S
Sbjct: 210 NYAIIGMSFYS 220


>gi|21242577|ref|NP_642159.1| phosphoribosylformimino-5- aminoimidazole carboxam [Xanthomonas
           axonopodis pv. citri str. 306]
 gi|24211777|sp|Q8PLG7|HIS4_XANAC 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase
           (Phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerase)
 gi|21108036|gb|AAM36695.1| phosphoribosylformimino-5- aminoimidazole carboxam [Xanthomonas
           axonopodis pv. citri str. 306]
          Length = 244

 Score = 37.0 bits (84), Expect = 0.32
 Identities = 42/190 (22%), Positives = 77/190 (40%), Gaps = 13/190 (6%)
 Frame = +1

Query: 133 AKLYKDRDVQGCHVIKLGPNNDDAAR-----------EALQESPQFLQVGGGINDTNCLE 279
           A+ + D   Q  H++ L     DAA+           E  + +   +Q GGG+     + 
Sbjct: 38  AQAFADAGAQWMHLVDL-----DAAKAGGYTLAGTLGEIARATGLRVQTGGGVRSREDVA 92

Query: 280 WL--KWASKVIVTSWLFTKEGHFQLKRLERLTELCGKDRIVVDLSCRKTQDGRWIVAMNK 453
            +    A++V++ S L  +     +  L+      G DR+ + L  R+  DG W + ++ 
Sbjct: 93  RILDAGAARVVIGS-LAVRNSEMVVGWLQEF----GADRLTIALDTRQDADGIWQLPVHG 147

Query: 454 WQTLTDLELNADTFRELRKYTNEFLIHAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVY 633
           W    D  L+    R  R      L      +G+  G +  L   L   T     L++  
Sbjct: 148 WTEAADATLDQLAVRYARAGLQHLLCTDIARDGMLSGPNMALYGHLRALT---PQLQVQV 204

Query: 634 AGGAKSVDDL 663
           +GGA+++ D+
Sbjct: 205 SGGARNLADV 214


>gi|18976741|ref|NP_578098.1| putative endoglucanase [Pyrococcus furiosus DSM 3638]
 gi|18892328|gb|AAL80493.1| putative endoglucanase [Pyrococcus furiosus DSM 3638]
          Length = 332

 Score = 35.4 bits (80), Expect = 0.93
 Identities = 23/71 (32%), Positives = 32/71 (45%)
 Frame = +1

Query: 520 EFLIHAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKVD 699
           E L     V G+  G +E +  K+ EW KDY D K+   G         L+ EL  G+V 
Sbjct: 5   EMLKEITQVPGI-SGYEERVREKIIEWIKDYADYKVDEIG--------NLIVELGEGEVK 55

Query: 700 LTFGSSLDIFG 732
             F + +D  G
Sbjct: 56  AVFMAHMDEIG 66


>gi|20455019|sp|Q9RPQ4|HIS6_THEET Imidazole glycerol phosphate synthase subunit hisF (IGP synthase
           cyclase subunit) (IGP synthase subunit hisF) (ImGP
           synthase subunit hisF) (IGPS subunit hisF)
 gi|6175608|gb|AAF05094.1|AF150930_3 cyclase [Thermoanaerobacter ethanolicus]
          Length = 254

 Score = 35.0 bits (79), Expect = 1.2
 Identities = 60/248 (24%), Positives = 98/248 (39%), Gaps = 10/248 (4%)
 Frame = +1

Query: 7   KFIGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDR----DVQGCHV 174
           + I C+D+HNG V + V         D  +        +SYY K   D     D+     
Sbjct: 5   RIIPCLDVHNGRVVKGVNFVNIRDAGDPVEI-------ASYYDKAGADELTFLDITAS-- 55

Query: 175 IKLGPNNDDAAREALQESPQFLQVGGGINDT-NCLEWLK-WASKVIVTSWLFTKEGHFQL 348
            +L     D  R   ++      VGGGI    +  E LK  A KV + S          +
Sbjct: 56  AELRNIMIDVVRRVAEQVFIPFTVGGGIRTVEDFREILKAGADKVSINS--------AAV 107

Query: 349 KRLERLTELC---GKDRIVVDLSCRKTQDGR-WIVAMNKWQTLTDLELNADTFRELRKYT 516
           KR E ++E     G   +VV +  ++  D   W V +N  +  T  +         +   
Sbjct: 108 KRPELISEAASRFGSQCVVVAIDAKRRDDNSGWDVYINGGRINTGKDAVEWAVEVEKLGA 167

Query: 517 NEFLIHAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKV 696
            E L+ + D +G   G D  L  K+ E  +    + ++ +GGA +++  +  + L  GK 
Sbjct: 168 GEILLTSMDCDGTKKGYDIELTRKVSESVR---MIPVIASGGAGTMEHFR--EALVEGKA 222

Query: 697 DLTFGSSL 720
           D    +SL
Sbjct: 223 DAVLAASL 230


>gi|23020792|ref|ZP_00060487.1| hypothetical protein [Clostridium thermocellum ATCC 27405]
          Length = 253

 Score = 34.7 bits (78), Expect = 1.6
 Identities = 59/246 (23%), Positives = 95/246 (38%), Gaps = 8/246 (3%)
 Frame = +1

Query: 7   KFIGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLG 186
           + I C+D+HNG V + V         D  +        +SYY K   D            
Sbjct: 5   RIIPCLDVHNGRVVKGVNFVNIRDAGDPVEI-------ASYYDKAGADELTFLDITASAE 57

Query: 187 PNN--DDAAREALQESPQFLQVGGGINDT-NCLEWLK-WASKVIVTSWLFTKEGHFQLKR 354
             N   D  R   ++      VGGGI    +  E LK  A KV + S          +KR
Sbjct: 58  ARNIMIDVVRRVAEQVFIPFTVGGGIRTVEDFREILKAGADKVSINS--------AAVKR 109

Query: 355 LERLTELC---GKDRIVVDLSCRKTQDGR-WIVAMNKWQTLTDLELNADTFRELRKYTNE 522
            E ++E     G   +VV +  ++  D   W V +N  +  T  +         +    E
Sbjct: 110 PELISEAASRFGSQCVVVAIDAKRRDDNSGWDVYINGGRINTGKDAVEWAVEVEKLGAGE 169

Query: 523 FLIHAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKVDL 702
            L+ + D +G   G D  L  K+ E  +    + ++ +GGA +++  +  + L  GK D 
Sbjct: 170 ILLTSMDCDGTKKGYDIELTRKVSESVR----IPVIASGGAGTMEHFR--EALVEGKADA 223

Query: 703 TFGSSL 720
              +SL
Sbjct: 224 VLAASL 229


>gi|24373629|ref|NP_717672.1| phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase [Shewanella oneidensis MR-1]
 gi|24347967|gb|AAN55116.1|AE015648_9 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase [Shewanella oneidensis MR-1]
          Length = 245

 Score = 34.7 bits (78), Expect = 1.6
 Identities = 50/215 (23%), Positives = 84/215 (39%), Gaps = 9/215 (4%)
 Frame = +1

Query: 142 YKDRDVQGCHVIKLGPNNDDAAREALQESPQF------LQVGGGIN-DTNCLEWLKWASK 300
           Y+ +D    H++ L    D A R+    +         +QVGGGI  +    E L    K
Sbjct: 38  YQAQDASWLHIVDLTGAKDPAKRQTALIAALTAGLSANIQVGGGIRTEEQVAELLSLGVK 97

Query: 301 VIVTSWLFTKEGHFQLKRLERLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQT--LTDL 474
            +V   L  KE         +     G + I + L    T  G  IVA++ WQ     +L
Sbjct: 98  RVVIGSLAVKEPELVKGWFNKF----GNEAICLALDINITPSGEKIVAVSGWQNGGGKNL 153

Query: 475 ELNADTFRELRKYTNEFLIHAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSV 654
           E   + F ++       L+     +G   G +  L  +L   +  Y ++    +GG  S+
Sbjct: 154 ESIVEDFSQVG--LKHALVTDISRDGTLTGANTELYCEL---SSRYPNIAWQASGGIASL 208

Query: 655 DDLKLVDELSHGKVDLTFGSSLDIFGGNLVKFEDC 759
           +D+  V +   G   +  G +L I   N+ +   C
Sbjct: 209 EDVAAVRD--SGAAGIIIGKALLINQFNVAEAIQC 241


>gi|15596654|ref|NP_250148.1| chemotaxis protein CheZ [Pseudomonas aeruginosa PA01]
 gi|11347561|pir||E83463 chemotaxis protein CheZ PA1457 [imported] - Pseudomonas aeruginosa
           (strain PAO1)
 gi|9947409|gb|AAG04846.1|AE004575_5 chemotaxis protein CheZ [Pseudomonas aeruginosa PAO1]
          Length = 262

 Score = 34.3 bits (77), Expect = 2.1
 Identities = 19/58 (32%), Positives = 33/58 (56%), Gaps = 1/58 (1%)
 Frame = +1

Query: 451 KWQTLTDLELNADTFRELRKYTNEFLIHAADVEG-LCGGIDELLVSKLFEWTKDYDDL 621
           +WQ     E++AD FREL K   +FL+ + +  G L   ++++L++      +DY DL
Sbjct: 128 EWQRFMRREIDADGFRELAKRIEQFLVRSGENAGQLSSQLNDILLA------QDYQDL 179


>gi|12644654|sp|Q51434|CHEZ_PSEAE Chemotaxis protein cheZ
          Length = 227

 Score = 34.3 bits (77), Expect = 2.1
 Identities = 19/58 (32%), Positives = 33/58 (56%), Gaps = 1/58 (1%)
 Frame = +1

Query: 451 KWQTLTDLELNADTFRELRKYTNEFLIHAADVEG-LCGGIDELLVSKLFEWTKDYDDL 621
           +WQ     E++AD FREL K   +FL+ + +  G L   ++++L++      +DY DL
Sbjct: 93  EWQRFMRREIDADGFRELAKRIEQFLVRSGENAGQLSSQLNDILLA------QDYQDL 144


>gi|15643795|ref|NP_228843.1| phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase [Thermotoga maritima]
 gi|20455029|sp|Q9X0C7|HIS4_THEMA 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase
           (Phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerase)
 gi|7437384|pir||D72304 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase - Thermotoga maritima (strain MSB8)
 gi|4981578|gb|AAD36114.1|AE001764_17 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase [Thermotoga maritima]
          Length = 241

 Score = 34.3 bits (77), Expect = 2.1
 Identities = 57/233 (24%), Positives = 99/233 (42%), Gaps = 10/233 (4%)
 Frame = +1

Query: 13  IGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLGPN 192
           +  IDL  G+V +++ G    +KE+   T F  + P     KL ++      HV+ L   
Sbjct: 4   VPAIDLFRGKVARMIKG----RKEN---TIFYEKDPVELVEKLIEEGFTL-IHVVDLSNA 55

Query: 193 NDDAAR-----EALQESPQFLQVGGGINDTNCLEWLKWAS--KVIVTSWLFTKEGHFQLK 351
            +++       E L E  + +Q+GGGI   +  E L+     + IV+S +   E    LK
Sbjct: 56  IENSGENLPVLEKLSEFAEHIQIGGGIRSLDYAEKLRKLGYRRQIVSSKVL--EDPSFLK 113

Query: 352 RLERLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFLI 531
            L  +         V  +    T+ GR  VA   W    +++      + L++Y  E ++
Sbjct: 114 SLREID--------VEPVFSLDTRGGR--VAFKGWLAEEEID-PVSLLKRLKEYGLEEIV 162

Query: 532 HAADVEGLCGGIDELLVSKLFEWTKDY---DDLKIVYAGGAKSVDDLKLVDEL 681
           H  ++E      D  L    F  TK      ++K++ AGG  S + LK   ++
Sbjct: 163 H-TEIEK-----DGTLQEHDFSLTKKIAIEAEVKVLAAGGISSENSLKTAQKV 209


>gi|11277584|pir||T46613 chemotaxis protein cheZ [validated] - Pseudomonas aeruginosa
 gi|961487|dbj|BAA07056.1| CheZ [Pseudomonas aeruginosa]
 gi|3721569|dbj|BAA33548.1| CheZ [Pseudomonas aeruginosa]
          Length = 227

 Score = 33.9 bits (76), Expect = 2.7
 Identities = 19/58 (32%), Positives = 32/58 (55%), Gaps = 1/58 (1%)
 Frame = +1

Query: 451 KWQTLTDLELNADTFRELRKYTNEFLIHAADVEG-LCGGIDELLVSKLFEWTKDYDDL 621
           +WQ     E++AD FREL K   +FL+   +  G L   ++++L++      +DY DL
Sbjct: 93  EWQRFMRREIDADGFRELAKRIEQFLVRTGENAGQLSSQLNDILLA------QDYQDL 144


>gi|19113034|ref|NP_596242.1| hypothetical zinc-finger protein [Schizosaccharomyces pombe]
 gi|7493751|pir||T39478 zinc-finger protein - fission yeast (Schizosaccharomyces pombe)
 gi|3451460|emb|CAA20477.1| hypothetical zinc-finger protein [Schizosaccharomyces pombe]
          Length = 547

 Score = 33.5 bits (75), Expect = 3.5
 Identities = 26/84 (30%), Positives = 37/84 (44%), Gaps = 3/84 (3%)
 Frame = -2

Query: 782 PCFSFHLQQSSNLTRLPPNISKELPNVKSTFP*LSSSTNFKSSTLLAPPA*TIFXXXXXX 603
           P  S HLQ  S LTRLPP  S  +    ++ P  + ++ + S   L PP+          
Sbjct: 32  PPNSLHLQHPSILTRLPPLSSSVVSPSLASLPPFTPTSTYHSIAALTPPS---------Y 82

Query: 602 XXXXXLETNNS--SIP-PHKPSTS 540
                  +NNS   +P PH PS +
Sbjct: 83  PQSSSAPSNNSYTIVPSPHDPSNA 106


>gi|9955269|pdb|1QO2|A Chain A, Crystal Structure Of N-((5'-Phosphoribosyl)-Formimino)-5-
           Aminoimidazol-4-Carboxamid Ribonucleotid Isomerase (Ec
           3.1.3.15, Hisa)
 gi|9955270|pdb|1QO2|B Chain B, Crystal Structure Of N-((5'-Phosphoribosyl)-Formimino)-5-
           Aminoimidazol-4-Carboxamid Ribonucleotid Isomerase (Ec
           3.1.3.15, Hisa)
          Length = 241

 Score = 33.5 bits (75), Expect = 3.5
 Identities = 57/233 (24%), Positives = 98/233 (42%), Gaps = 10/233 (4%)
 Frame = +1

Query: 13  IGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLGPN 192
           +  IDL  G+V + + G    +KE+   T F  + P     KL ++      HV+ L   
Sbjct: 4   VPAIDLFRGKVARXIKG----RKEN---TIFYEKDPVELVEKLIEEGFTL-IHVVDLSNA 55

Query: 193 NDDAAR-----EALQESPQFLQVGGGINDTNCLEWLKWAS--KVIVTSWLFTKEGHFQLK 351
            +++       E L E  + +Q+GGGI   +  E L+     + IV+S +   E    LK
Sbjct: 56  IENSGENLPVLEKLSEFAEHIQIGGGIRSLDYAEKLRKLGYRRQIVSSKVL--EDPSFLK 113

Query: 352 RLERLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFLI 531
            L  +         V  +    T+ GR  VA   W    +++      + L++Y  E ++
Sbjct: 114 SLREID--------VEPVFSLDTRGGR--VAFKGWLAEEEID-PVSLLKRLKEYGLEEIV 162

Query: 532 HAADVEGLCGGIDELLVSKLFEWTKDY---DDLKIVYAGGAKSVDDLKLVDEL 681
           H  ++E      D  L    F  TK      ++K++ AGG  S + LK   ++
Sbjct: 163 H-TEIEK-----DGTLQEHDFSLTKKIAIEAEVKVLAAGGISSENSLKTAQKV 209


>gi|477064|pir||A47754 1-(5-phosphoribosyl)-5-[
           (5-phosphoribosylamino)methylideneamino)imidazole-4-
           carboxam ide isomerase (EC 5.3.1.16) HisA [similarity] -
           Lactococcus lactis subsp. lactis
 gi|2565146|gb|AAB81908.1| HisA [Lactococcus lactis]
          Length = 239

 Score = 33.5 bits (75), Expect = 3.5
 Identities = 48/226 (21%), Positives = 88/226 (38%), Gaps = 6/226 (2%)
 Frame = +1

Query: 7   KFIGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLG 186
           K I  IDL NGE  ++  G       D  K    S++P    A+ ++       H++ L 
Sbjct: 2   KIIPAIDLQNGEAVRLYKG-------DYDKKTVYSKNPLE-IAQKFERMGATDLHLVDLD 53

Query: 187 ------PNNDDAAREALQESPQFLQVGGGINDTNCLEWLKWASKVIVTSWLFTKEGHFQL 348
                   N +  R+   E+   +++GGGI D + +    +  ++ V   +       + 
Sbjct: 54  GAKIGQTRNLELVRKIKDETRLKIEIGGGIRDFDTVR--MYLEQIGVERVILGTAAVEKP 111

Query: 349 KRLERLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFL 528
             L+ L    G  RIVV +  R+       V+ + W   T L   +   +  R      +
Sbjct: 112 DFLKELLIKYGPSRIVVGVDIRE-----GFVSTSGWLEKTSLPYLSFLKKLERIGVKTTI 166

Query: 529 IHAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLK 666
           I     +G   G +     KL++     + L ++ +GG K   D++
Sbjct: 167 ITDISKDGTLTGPN----FKLYDEISKENSLNVIISGGVKDNSDIQ 208


>gi|15794037|ref|NP_283859.1| putative pantoate--beta-alanine ligase [Neisseria meningitidis
           Z2491]
 gi|9978473|sp|P57035|PANC_NEIMA Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate
           activating enzyme)
 gi|11279933|pir||F81874 probable pantoate-beta-alanine ligase (EC 6.3.2.1) NMA1089
           [imported] - Neisseria meningitidis (strain Z2491
           serogroup A)
 gi|7379784|emb|CAB84352.1| putative pantoate--beta-alanine ligase [Neisseria meningitidis
           Z2491]
          Length = 278

 Score = 33.1 bits (74), Expect = 4.6
 Identities = 30/119 (25%), Positives = 52/119 (43%), Gaps = 8/119 (6%)
 Frame = +1

Query: 322 FTKEGHFQLKRLERLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRE 501
           F K+ + QL  ++ LTE    D  +V +   + +DG  + + N++ +  + +     +RE
Sbjct: 143 FGKKDYQQLAVIKGLTEDLNFDVEIVPVDTGRAEDGLALSSRNQYLSAAERDEAPRLYRE 202

Query: 502 LRKYTNEFLIHAADVEGLCGGIDELLVSKLFE--WTKDY------DDLKIVYAGGAKSV 654
           L+         + D  GL    ++  V  L E  W  DY      D L++  AG  K V
Sbjct: 203 LKAVAESLAQGSLDYAGL----EKRAVQSLTEYGWVVDYVEIRRVDTLEVARAGDKKLV 257


>gi|20455018|sp|Q9RDX2|HIS6_LEGPN Imidazole glycerol phosphate synthase subunit hisF (IGP synthase
           cyclase subunit) (IGP synthase subunit hisF) (ImGP
           synthase subunit hisF) (IGPS subunit hisF)
 gi|6688606|emb|CAB65215.1| HisF protein [Legionella pneumophila]
          Length = 212

 Score = 33.1 bits (74), Expect = 4.6
 Identities = 34/144 (23%), Positives = 63/144 (43%), Gaps = 3/144 (2%)
 Frame = +1

Query: 238 LQVGGGINDTNCLEWLK--WASKVIVTSWLFTKEGHFQLKRLERLTELCGKDRIVVDLSC 411
           + VGGGI   +  E L    A KV + +   TK        +  +    G   +V+ +  
Sbjct: 77  ITVGGGIRSVDDAEQLLRCGADKVAINT-AATKNPTL----ISDIARRFGSQCVVLSIEA 131

Query: 412 RKTQDGRWIVAMNKWQTLTDLELNADTFRELRKY-TNEFLIHAADVEGLCGGIDELLVSK 588
           ++T +GRW V  +  +  T +++  D  R   K+   E L+ + D EG   G D  LV +
Sbjct: 132 KRTVNGRWEVMTDNGREHTGMDV-VDWARNGEKFGAGEILLTSIDQEGTRKGFDLELVKQ 190

Query: 589 LFEWTKDYDDLKIVYAGGAKSVDD 660
           +         + ++ +GG   +++
Sbjct: 191 VSSMV----SIPVIASGGMGKLEE 210


>gi|27375764|ref|NP_767293.1| phosphoribosylformino-5-aminoimidazole carboxamide ribotide
           isomerase [Bradyrhizobium japonicum]
 gi|27348902|dbj|BAC45918.1| phosphoribosylformino-5-aminoimidazole carboxamide ribotide
           isomerase [Bradyrhizobium japonicum]
          Length = 248

 Score = 32.7 bits (73), Expect = 6.0
 Identities = 53/225 (23%), Positives = 93/225 (41%), Gaps = 10/225 (4%)
 Frame = +1

Query: 22  IDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLG----- 186
           IDL NG+  ++  G       D+ +    + +P++  A+ + ++  +  HV+ L      
Sbjct: 10  IDLKNGQCVRLEQG-------DMARATVFNLNPAAQ-AQSFAEQGFEYLHVVDLDGAFAG 61

Query: 187 -PNNDDAAREALQESPQFLQVGGGINDTNCLE-WLKWASKVIVTSWLFTKEGHFQLKRLE 360
            P N  A    L+     +Q+GGGI D   +E WL+     ++      ++        +
Sbjct: 62  KPVNAQAVEAMLKTIKIPVQLGGGIRDLATVEAWLEKGITRVIIGTAAVRDPDLVKAAAK 121

Query: 361 RLTELCGKDRIVVDLSCRKTQDGRWIVAMNKW---QTLTDLELNADTFRELRKYTNEFLI 531
           +        R+ V L  R   DG+  VA+  W     +T LE+ A  F +       F  
Sbjct: 122 KFP-----GRVAVGLDAR---DGK--VAVEGWAETSQVTALEI-AQRFEDAGVAAIIFTD 170

Query: 532 HAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLK 666
            A D  GL  G++      L     D   + ++ +GG  S+DD+K
Sbjct: 171 IARD--GLLKGLNLDATIAL----ADSISIPVIASGGLASIDDVK 209


>gi|7484628|pir||T12288 O-succinylhomoserine (thiol)-lyase (EC 4.2.99.9) - common ice plant
 gi|3202028|gb|AAC19395.1| cystathionine gamma-synthase [Mesembryanthemum crystallinum]
          Length = 548

 Score = 32.7 bits (73), Expect = 6.0
 Identities = 30/93 (32%), Positives = 41/93 (44%), Gaps = 14/93 (15%)
 Frame = +1

Query: 487 DTFRELRKYTNEFL---------IHAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAG 639
           D +R+ R +   FL         I  ADVEGL   +DE  V+  F  +     L+ V   
Sbjct: 264 DCYRKTRIFIETFLPKMGITATVIDPADVEGLKSALDENNVTLFFTESPTNPFLRCV--- 320

Query: 640 GAKSVDDLKLVDELSHGK-----VDLTFGSSLD 723
                 D+KLV EL H K     +D TF + L+
Sbjct: 321 ------DIKLVSELCHKKGALVCIDGTFATPLN 347


>gi|14193302|gb|AAK55887.1|AF267210_2 ATP synthase gamma subunit [Candidatus Carsonella ruddii]
          Length = 252

 Score = 32.3 bits (72), Expect = 7.9
 Identities = 31/104 (29%), Positives = 53/104 (50%), Gaps = 12/104 (11%)
 Frame = +1

Query: 382 KDRIVVDLSCRKTQDGRWIVAM------NKWQT-LTDL-ELNADTFRELRKYTNEFL--- 528
           K++I +  +  K  +   ++AM      NK+ T L DL E + D F  L+K  N  +   
Sbjct: 7   KNKINIISNINKLTNTMSMIAMSKMNKFNKYLTILNDLYEESKDIFNLLKKKNNSIIYCC 66

Query: 529 IHAADVEGLCGGIDELLVSKLFEWTKDYD-DLKIVYAGGAKSVD 657
           I     +GLCG I+  ++ K   + K+Y+ D+ ++   G KS+D
Sbjct: 67  IIITSNKGLCGSINNEILKKSLNFIKNYNCDIILI---GKKSID 107


>gi|15897511|ref|NP_342116.1| Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase (hisA) [Sulfolobus solfataricus]
 gi|3913855|sp|O33772|HIS4_SULSO 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase
           (Phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerase)
 gi|25292632|pir||C90206 hypothetical protein hisA [imported] - Sulfolobus solfataricus
 gi|2253621|gb|AAB63020.1| phosphoribosyl-formimino-5-amino-1-phosphoribosyl-4-imidazole
           carboxamide isomerase [Sulfolobus solfataricus]
 gi|6015878|emb|CAB57705.1| HisA, (phosphoribosylformimino-5-amino-1-phosphoribosyl-4-
           imidazole [Sulfolobus solfataricus]
 gi|13813760|gb|AAK40906.1| Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
           isomerase (hisA) [Sulfolobus solfataricus]
          Length = 232

 Score = 32.3 bits (72), Expect = 7.9
 Identities = 57/234 (24%), Positives = 93/234 (39%), Gaps = 13/234 (5%)
 Frame = +1

Query: 1   MTKFIGCIDLHNGE-VKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVI 177
           M + I  ID+  G+ VK+I G         V  T  V  +P     KLY +      HV+
Sbjct: 1   MNEIIPSIDISFGKAVKRIRG---------VRGTGLVLGNPIELANKLYNE-GYSRIHVV 50

Query: 178 KLGP-----NNDDAAREALQESPQFLQVGGGINDTNCLEWLKWASKVIVTSWLFTKEGHF 342
            L       NN+   +E  +    ++QVGGGI D   +E  K    + V + +F+     
Sbjct: 51  DLDAAEGVGNNEMYIKEICKIGFDWIQVGGGIRD---VEKAKRLISLDVNALIFSTIVFT 107

Query: 343 QLKRLERLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNE 522
                  +    G +R++V +    T+     V ++ W+     E + +    ++K  NE
Sbjct: 108 NFNLFYNIVREIGNNRVIVSIDYDDTKR----VLISGWK-----ERSMEIIDGIKK-VNE 157

Query: 523 -----FLIHAADVEGLCGGIDELL--VSKLFEWTKDYDDLKIVYAGGAKSVDDL 663
                 ++     EG   GID  +   +KL    K+       YAGG  S  D+
Sbjct: 158 LELLGIILTYVTNEGTVKGIDYSVKDYAKLIRGVKE-------YAGGVSSDSDI 204


>gi|20089116|ref|NP_615191.1| N-(5-phospho-D-ribosylformimino)-5-amino-1-(5-phosphoribosyl)-4-
           imidazole carboxamide isomerase [Methanosarcina
           acetivorans str. C2A]
 gi|22095764|sp|Q8TU55|HIS4_METAC 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase
           (Phosphoribosylformimino-5-aminoimidazole carboxamide
           ribotide isomerase)
 gi|19913982|gb|AAM03671.1| N-(5-phospho-D-ribosylformimino)-5-amino-1-(5-phosphoribosyl)-4-
           imidazole carboxamide isomerase [Methanosarcina
           acetivorans str. C2A]
          Length = 245

 Score = 32.3 bits (72), Expect = 7.9
 Identities = 55/251 (21%), Positives = 103/251 (41%), Gaps = 15/251 (5%)
 Frame = +1

Query: 13  IGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLGPN 192
           I  +D+  G+  Q+V G        VP +  VS +     A  +  +  +  H++ L   
Sbjct: 6   IPAVDMRGGKCVQLVQG--------VPGSEIVSLNDPLAVALDWIGKGAKTLHLVDLDGA 57

Query: 193 NDDAAR---------EALQESPQFLQVGGGIN---DTNCLEWLKWASKVIVTSWLFTKEG 336
            +   +         +A +E    +QVGGGI    D   L  L  +  ++ T+ L   E 
Sbjct: 58  IEGERKNAPIIEKIVQACREKGVSIQVGGGIRSFEDAASLLELGVSRIILGTAALQNPE- 116

Query: 337 HFQLKRLERLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQ---TLTDLELNADTFRELR 507
                 +++L++  G   + V L  +  +     +++  W      T +E+  + F EL 
Sbjct: 117 -----LVKQLSDAFGSSCVNVALDAKNGK-----ISIKGWTEECAQTPVEMGRE-FEELG 165

Query: 508 KYTNEFLIHAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSH 687
                 L    D EGL  G++     +L E       + ++ +GG  S++DLK++ +   
Sbjct: 166 --AGSLLFTNIDTEGLMQGVNPGPTRELVESVS----IPVIASGGVSSLEDLKVLKQT-- 217

Query: 688 GKVDLTFGSSL 720
           G   +  GS+L
Sbjct: 218 GASGVVVGSAL 228


>gi|20086391|dbj|BAB88833.1| axonemal p66.0 [Ciona intestinalis]
          Length = 575

 Score = 32.3 bits (72), Expect = 7.9
 Identities = 32/135 (23%), Positives = 62/135 (45%), Gaps = 5/135 (3%)
 Frame = +1

Query: 349 KRLERLTELCGKDRIVVDLS-CRKTQDGRWIVAMNKWQTLTDLELNADTFRELR----KY 513
           K  E++ E+ G+  I + +S   +T+D  + +     +   +LEL  +   ++R    ++
Sbjct: 299 KAFEKIQEVTGEGDIYLLVSRFIETEDKNFALFNYVNELNNELELIQEQIDDVRMQIEQF 358

Query: 514 TNEFLIHAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGK 693
            NE + H  + + +  G++E    KL + TK+ D          K +D LK   E   GK
Sbjct: 359 KNEGVQHQVERQNILKGLEE----KLRKTTKEADMFDKQLKATEKILDQLKAGIESVFGK 414

Query: 694 VDLTFGSSLDIFGGN 738
           ++    +  D+ G N
Sbjct: 415 INCNRSTISDMLGDN 429


  Database: All non-redundant GenBank CDS
  translations+PDB+SwissProt+PIR+PRF
    Posted date:  Mar 20, 2003 11:48 PM
  Number of letters in database: 442,128,549
  Number of sequences in database:  1,376,251
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 599,282,054
Number of Sequences: 1376251
Number of extensions: 11703612
Number of successful extensions: 34249
Number of sequences better than 10.0: 92
Number of HSP's better than 10.0 without gapping: 32202
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 34173
length of database: 442,128,549
effective HSP length: 121
effective length of database: 275,602,178
effective search space used: 38584304920
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)